CPN1, carboxypeptidase N subunit 1, 1369

N. diseases: 31; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242966
Disease: Systemic Inflammatory Response Syndrome
Systemic Inflammatory Response Syndrome 		0.010 Biomarker disease BEFREE The L<sub>A</sub>-Sepsis CPN also has a modest ability to discriminate between sepsis and non-infectious SIRS. 27833000 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 Biomarker disease BEFREE The L<sub>A</sub>-Sepsis CPN also has a modest ability to discriminate between sepsis and non-infectious SIRS. 27833000 2017
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor 		0.010 Biomarker disease BEFREE In the present study, we examined the expression of glucose transporters (GLUT-1, GLUT-4) and fatty acids transporters (FAT/CD36, FATP-1, FATP-4) at transcript and protein levels as well as cytosolic fatty acid binding proteins (H-FABP, ACBP) in human fibroids (n=74, size up to 3cm diameter) and compared with pair-matched healthy myometrium. 26932421 2016
CUI: C0042133
Disease: Uterine Fibroids
Uterine Fibroids 		0.010 Biomarker group BEFREE In the present study, we examined the expression of glucose transporters (GLUT-1, GLUT-4) and fatty acids transporters (FAT/CD36, FATP-1, FATP-4) at transcript and protein levels as well as cytosolic fatty acid binding proteins (H-FABP, ACBP) in human fibroids (n=74, size up to 3cm diameter) and compared with pair-matched healthy myometrium. 26932421 2016
CUI: C0221056
Disease: Adult type dermatomyositis
Adult type dermatomyositis 		0.010 GeneticVariation disease BEFREE Moreover, we identified two novel suggestive susceptibility loci (PIP and CPN1) and confirmed four previously reported genes (DMB, DQA1, DQB1 and DRB1) having potential associations with DM in the Chinese Han population. 27153935 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE These findings suggest that PGC‑1α may promote cell proliferation and tumorigenesis through upregulation of ACBP. 25585584 2015
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 Biomarker group BEFREE Collectively, CPN-9 is a novel Nrf2 activator and a neuroprotective candidate for the treatment of neurodegenerative diseases, including ALS. 23000247 2012
CUI: C0010200
Disease: Coughing
Coughing 		0.010 AlteredExpression phenotype BEFREE In addition, genetic interactions between peptidases involved in kinins levels (CPN1 and XPNPEP1) and proteins related to prostaglandin metabolism (PTGIS and PTGIR) strongly modify the risk of ACEi-induced cough presentation (0.102≤OR≤0.384 for protective combinations and 2.732≤OR≤7.216 for risk combinations). 21052031 2011
CUI: C3160909
Disease: Autoimmune arthritis
Autoimmune arthritis 		0.010 Biomarker disease BEFREE Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. 21804193 2011
CUI: C0002792
Disease: anaphylaxis
anaphylaxis 		0.010 Biomarker phenotype BEFREE CPN1(-/-) mice were hypersensitive to lethal anaphylactic shock due to acute complement activation by cobra venom factor. 19414808 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 GeneticVariation disease BEFREE We examined brain specimens from 19 VaD patients, 16 elderly normal people and four Alzheimer's disease (AD) patients for the presence of a sequence in the Cpn gene for rRNA, using polymerase chain reaction (PCR) and taking stringent precautions against contamination. 12927758 2003