|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly, treatment of a mouse model of AD, the APP/PS1-mice, with GW0742 increased the expression of Cpt1a and concomitantly reversed memory deficits in a fear conditioning test.
|
30453390 |
2019 |
|
Encephalomyelitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, mice with downregulated lipid metabolism due to the Cpt1a P479L mutation showed resistance to EAE induction.
|
31527712 |
2019 |
|
Hypertriglyceridemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, the splicing of the β-oxidation enzyme, CPT1, was altered in the SF2-RNAi flies potentially promoting the increased triglycerides in these animals.
|
31277943 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, this study reveals a novel mechanism of S100A10 accumulation mediated by succinylation in GC, which promotes GC progression and is regulated by the succinyltransferase CPT1A and SIRT5-mediated desuccinylation.
|
30394687 |
2019 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis.
|
31527712 |
2019 |
|
Medium-chain acyl-coenzyme A dehydrogenase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eighty-three clinical charts, including 66 medium-chain acyl-CoA dehydrogenase deficiency (MCADD), 5 carnitine-uptake deficiency (CUD), 3 carnitine palmitoyltransferase I and II (CPT I/II) deficiency, 5 very long-chain acyl-CoA dehydrogenase deficiency (VLCADD), and 4 multiple acyl-CoA dehydrogenase deficiency (MADD) cases were reviewed.
|
30617651 |
2019 |
|
Memory impairment
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Similarly, treatment of a mouse model of AD, the APP/PS1-mice, with GW0742 increased the expression of Cpt1a and concomitantly reversed memory deficits in a fear conditioning test.
|
30453390 |
2019 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
When administrated alone, caffeine (5 and 50 mg/kg) and 8-CPT (1 and 5 mg/kg) significantly decreased seizure threshold, while 100 mg/kg of caffeine, SCH-442416 or sildenafil did not change it.
|
30391360 |
2019 |
|
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eighty-three clinical charts, including 66 medium-chain acyl-CoA dehydrogenase deficiency (MCADD), 5 carnitine-uptake deficiency (CUD), 3 carnitine palmitoyltransferase I and II (CPT I/II) deficiency, 5 very long-chain acyl-CoA dehydrogenase deficiency (VLCADD), and 4 multiple acyl-CoA dehydrogenase deficiency (MADD) cases were reviewed.
|
30617651 |
2019 |
|
Renal carnitine transport defect
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eighty-three clinical charts, including 66 medium-chain acyl-CoA dehydrogenase deficiency (MCADD), 5 carnitine-uptake deficiency (CUD), 3 carnitine palmitoyltransferase I and II (CPT I/II) deficiency, 5 very long-chain acyl-CoA dehydrogenase deficiency (VLCADD), and 4 multiple acyl-CoA dehydrogenase deficiency (MADD) cases were reviewed.
|
30617651 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, this study reveals a novel mechanism of S100A10 accumulation mediated by succinylation in GC, which promotes GC progression and is regulated by the succinyltransferase CPT1A and SIRT5-mediated desuccinylation.
|
30394687 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions.
|
31547059 |
2019 |
|
Pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
CPT1 regulates the proliferation of pulmonary artery smooth muscle cells through the AMPK-p53-p21 pathway in pulmonary arterial hypertension.
|
30511343 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that CPT1 was highly expressed in rat lungs and pulmonary arteries in monocrotaline-induced PAH, accompanied by decreased adenosine triphosphate (ATP) production and downregulation of the AMPK-p53-p21 pathway.
|
30511343 |
2019 |
|
Cooley's anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, a low level of free carnitine and acylcarnitines together with impaired CPT-1 activity contribute to energy crisis-related complications in the patients with BTM.
|
30046479 |
2018 |
|
Developmental Disabilities
|
0.010 |
Biomarker
|
group |
BEFREE |
Two patients with LCHAD/MTP deficiencies died due to severe cardiomyopathy in the neonatal period, and developmental disability was noted in CPT1A deficiency (1 patient).
|
29519241 |
2018 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Hence, endothelial loss of FAO-controlling CPT1A in CPT1A<sup>ΔEC</sup> mice promotes EC dysfunction (leukocyte infiltration, barrier disruption) by increasing endothelial oxidative stress, rendering CPT1A<sup>ΔEC</sup> mice more susceptible to LPS and inflammatory bowel disease.
|
30146488 |
2018 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased protein expression of PPAR-γ was accompanied by up regulation in SREBP1c, FAS, CPT-1 and ACC-1 genes in PCOS-IR group.
|
29339197 |
2018 |
|
Niemann-Pick Disease, Type C
|
0.010 |
Biomarker
|
disease |
BEFREE |
NPC tumor tissue microarray was used to investigate the prognostic role of CPT1A.
|
29721083 |
2018 |
|
Transient erythroblastopenia of childhood
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BBR significantly up-regulated the protein expression of CPT1A, PPARα, and PGC1α in TECs treated with or without PA, and reversed PA-induced intracellular lipid accumulation and apoptosis.
|
29528039 |
2018 |
|
Dyslipidemias
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Even so, NP-1 ameliorated fatty liver and corrected dyslipidemia by mechanisms probably associated with reduced feeding, transcription of Cpt1 and down-regulation of Hmgcr-CoA expression.
|
29959379 |
2018 |
|
Muscle damage
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our previous research demonstrated that Platycodon grandiflorum-derived saponin (PS) protects against eccentric exercise-induced muscle damage and mitochondrial function-related peroxisomal acyl-coenzme A oxidase (ACOX-1) and carnitine palmitoyltransferase (CPT-1) in high-fat diet-induced non-alcoholic steatohepatitis, and it inhibits osteoclast differentiation.
|
29723585 |
2018 |
|
Lymphangioleiomyomatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of p-S6 (mTORC1 downstream protein), Rictor (mTORC2 scaffold protein) as well as GLUT1, GAPDH, ATPB, GLS, MCT1, ACSS2 and CPT1A (metabolic pathway markers) were performed on lung tissue from 11 patients with sporadic LAM.
|
29885404 |
2018 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, fatty acids oxidation axis PPARα-CD36-CPT1A was involved in the pro-angiogenic roles of DQP against CAD.
|
30564122 |
2018 |
|
TDP-43 Proteinopathies
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate that components of the carnitine shuttle are misexpressed in the context of TDP-43 proteinopathy and that genetic modulation of CPT1 or CPT2 expression, two core components of the carnitine shuttle, mitigates TDP-43 dependent locomotor dysfunction, in a variant dependent manner.
|
29904341 |
2018 |