Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
Biomarker
|
disease |
CTD_human |
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
|
16123366 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Neither haplotypes nor SNPs of CPT1A were found to be associated either with susceptibility to type 2 diabetes mellitus or with HLC or insulin resistance in type 2 diabetic patients.
|
17445541 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
Biomarker
|
disease |
RGD |
Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.
|
19553925 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
We replicated in the Qatari population seven CpG associations with BMI (SOCS3, p value = 3.99 × 10(-6); SREBF1, p value = 4.33 × 10(-5); SBNO2, p value = 5.87 × 10(-5); CPT1A, p value = 7.99 × 10(-5); PRR5L, p value = 1.85 × 10(-4); cg03078551, intergenic region on chromosome 17; p value = 1.00 × 10(-3); LY6G6E, p value = 1.10 × 10(-3)) and one with T2D (TXNIP, p value = 2.46 × 10(-5)).
|
26823690 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
Biomarker
|
disease |
BEFREE |
Histological results confirmed that renal expression of key proteins was reduced in DKD patients with respect to mitochondrial biogenesis (PGC-1α, p-AMPK) and FA oxidation (PPAR-α, CPT-1) as compared to that in the control and T2DM groups.
|
28956034 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Results showed that VK1 supplementation [1, 3, 5 μg/kg body weight (BW), 8 weeks] dose dependently improved the glucose tolerance; decreased BW gain, fasting glucose and insulin, glycated hemoglobin, HOMA-IR and cytokine secretion (monocyte chemoattractant protein-1 and interleukin-6); and regulated the signaling pathway of hepatic glucose metabolism [sirtuin 1 (SIRT1)/AMP-activated protein kinase (AMPK)/phosphoinositide 3-kinase/phosphatase and tensin homolog/glucose transporter 2/glucokinase/glucose 6 phosphatase], lipid oxidation (peroxisome proliferator-activated receptor alpha/carnitine palmitoyltransferase 1A) and inflammation (nuclear factor kappa B) in T2D mice.
|
29175667 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Four DMPs [cg19693031 (TXNIP), cg04816311 (C7orf50), cg00574958 (CPT1A), cg07988171 (TPM4)] were associated with T2D after correction for inflation by possible systematic biases.
|
30107520 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.560 |
Biomarker
|
disease |
BEFREE |
Th17 function requires fatty acid uptake, and our new data show that blockade of CPT1A inhibits Th17-associated cytokine production by cells from people with type 2 diabetes (T2D).
|
31378464 |
2019 |