Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
<b>Objective:</b> AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models.
|
29731721 |
2018 |
Atherosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
<b>Objective:</b> AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models.
|
29731721 |
2018 |
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion.
|
21700930 |
2011 |
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.
|
25732743 |
2015 |
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.
|
25732743 |
2015 |
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis.
|
26139244 |
2015 |
Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
AIP1 is demonstrated to inhibit Aβ42 oligomerization and fibrillation and to rescue Aβ42-induced cytotoxicity through decreasing the content of Aβ42 oligomers that is related to cell membrane permeability.
|
27714968 |
2017 |
Follicular atrophoderma and basal cell epitheliomata
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
ARP-T1 was found to directly bind to the GLI1 promoter, thus inhibiting GLI1 expression, and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS.
|
28869610 |
2017 |
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
AIP1 could be a promising biomarker for predicting ESCC prognosis and a potential target for anti-angiogenic therapy.
|
30464518 |
2018 |
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ.
|
30471213 |
2019 |
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
|
22046421 |
2011 |
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
|
22046421 |
2011 |
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
|
22046421 |
2011 |
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Approach and Results: We detected a normal AIP1 form (named AIP1A) in the healthy aorta, but a shorter form of AIP1 (named AIP1B) was found in diseased aortae that contained atherosclerotic plaques and graft arteriosclerosis.
|
31619063 |
2020 |
Amyloidosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By screening a peptoid library using surface plasmon resonance imaging, amyloid inhibitory peptoid 1 (AIP1) that has high affinity to Aβ42 is identified.
|
27714968 |
2017 |
Malignant melanoma of eye
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.
|
15366927 |
2004 |
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC).<i>Conclusion</i>.
|
28348580 |
2017 |
Columnar Cell Change of the Breast
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC).<i>Conclusion</i>.
|
28348580 |
2017 |
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Hookworm recombinant AIP-1 is a novel therapeutic candidate for the treatment of inflammatory bowel diseases that can be explored for the prevention of acute inflammatory relapses, an important cause of colorectal cancer.
|
29114386 |
2017 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hookworm recombinant AIP-1 is a novel therapeutic candidate for the treatment of inflammatory bowel diseases that can be explored for the prevention of acute inflammatory relapses, an important cause of colorectal cancer.
|
29114386 |
2017 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hookworm recombinant AIP-1 is a novel therapeutic candidate for the treatment of inflammatory bowel diseases that can be explored for the prevention of acute inflammatory relapses, an important cause of colorectal cancer.
|
29114386 |
2017 |
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the direct role of AIP1 in endothelium, vascular remodeling and associated vascular diseases has not been determined.
|
29731721 |
2018 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the role of AIP1 in the tumor microenvironment has not been examined.
|
26139244 |
2015 |
Carcinoma, Basal Cell
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
In summary, our study identifies a disease mechanism in BCC involving mutations in regulatory noncoding elements and uncovers the tumor-suppressor properties of ACTRT1.
|
28869610 |
2017 |
Experimental Organism Basal Cell Carcinoma
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In summary, our study identifies a disease mechanism in BCC involving mutations in regulatory noncoding elements and uncovers the tumor-suppressor properties of ACTRT1.
|
28869610 |
2017 |