|
Adenocarcinoma of lung (disorder)
|
0.380 |
Biomarker
|
disease |
BEFREE |
Rac3 Regulates Cell Invasion, Migration and EMT in Lung Adenocarcinoma through p38 MAPK Pathway.
|
28900489 |
2017 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Further, we demonstrated that neither JNK2 nor p38 siRNAmediated inhibition led to significant change of CML cell proliferation.
|
17949234 |
2007 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
In this work we report evidences of a functional relationship between C3G and p38 MAPK in the apoptotic effect of STI-571 on the chronic myeloid leukemia (CML) cell line K562.
|
19324082 |
2009 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells.
|
28133573 |
2017 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
In this study, we found that treatment with ABL kinase inhibitors or depletion of BCR-ABL induced the expression of RAB45 messenger RNA and protein and induced apoptosis via reduction of mitochondrial membrane potential and p38 activation in CML cell lines and BCR-ABL(+) progenitor cells from CML patients.
|
21890458 |
2011 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that such dasatinib-dependent activation of p38 MAPK and its effectors plays a critical role in the generation of antileukemic responses, since pharmacological inhibition of p38 or siRNA-mediated knockdown of its expression reverse dasatinib-mediated apoptosis, cell cycle arrest, and anti-proliferative effects. p38 MAPK inhibition also reversed dasatinib-induced suppression of CML patient-derived leukemic colony-forming units progenitor growth in vitro, as well as BCR/ABL expressing KT-1 cell-derived leukemic progenitor growth.
|
19672773 |
2009 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that IKKα signaling promotes increased cell malignancy of NSCLC cells as well as lung tumor progression and metastasis in either subcellular localization, through activation of common protumoral proteins, such as Erk, p38 and mTor.
|
30867890 |
2019 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Furthermore, both Kras-driven mouse lung tumors and orthotopically grown primary human lung cancers show a significant sensitivity to both a chemical p38 inhibitor and an over-the-counter inhibitor of hyaluronan synthesis.
|
28007785 |
2016 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Examination of signaling molecules downstream of the IGF-IR showed the activation of either the Erk1/Erk2 or p38 MAPK pathways, but not both, within the lung tumors.
|
12584565 |
2003 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Hypoxia-inducible factor-1α, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years. p38 MAPK is also activated in Cr(VI)-transformed cells and in human lung tumor tissue.
|
27226640 |
2016 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
|
16951197 |
2006 |
|
Liver neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
We have previously shown that the p38 MAPK inhibitor SB203580 (SB) significantly induced Cyp1a1 gene expression at the mRNA and activity levels, whereas it dramatically inhibited the induction of Cyp1a1 by TCDD in murine hepatoma Hepa 1c1c7 cells.
|
21732638 |
2011 |
|
Liver neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
We analysed the involvement of MAPK homologues in IL-6 transduction pathways and found that interleukin-6 triggered activation of p38 stress-activated protein kinase (p38) but not of jun kinase. p38 activity was required for biological functions including acute phase protein secretion from HepG2 hepatoma and proliferation of B9 hybridoma cells.
|
10445852 |
1999 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
We hypothesized pallidin and p38 play a role in neural system development and the pathogenesis of schizophrenia, and designed several experiments to test this possibility.
|
28035416 |
2017 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We also demonstrated that this new variant ss178077483, combined with mir-30e rs7556088 and mir-24-MAPK14 rs3804452, showed a weak gene-gene interaction for schizophrenia risk (P=0.001).
|
20347265 |
2010 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Variants of the mitogen-activated protein kinase 14 gene (MAPK14) and the phosphoenolpyruvate carboxykinase 1 (PCK1) and fructose-1,6-biphosphatase (FBP1) were nominal significantly associated with schizophrenia, and several haplotypes within enolase 2 gene (ENO2) consist of the same SNP allele having elevated risk of schizophrenia.
|
18460190 |
2008 |
|
Myocardial Ischemia
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In this model of myocardial ischemia and reperfusion, Bcl-2 expression was increased and was associated with increased p38 MAPK activation.
|
20307495 |
2010 |
|
Myocardial Ischemia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Specific inhibition of the p38 mitogen-activated protein kinase pathway with SB 203580 almost completely blocked apoptosis mediated by pericardial fluid from ischemic heart disease.
|
11181011 |
2001 |
|
Myocardial Ischemia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia.
|
30135318 |
2018 |
|
Depressive Symptoms
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these findings indicate that sensitivity of p38 MAPK signaling pathways to immune stimulation is associated with depressive symptoms during chronic IFN-alpha treatment.
|
21356304 |
2011 |
|
Depressive Symptoms
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Altered p38 MAPK expression was associated with poor outcome in patients with esophageal cancer. p38 may be a potential biomarker for the prediction of depressive symptoms and prognosis in patients with esophageal cancer.
|
29344159 |
2017 |
|
Marijuana Abuse
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Of the MAPK14 tSNPs, only rs12199654 had significant genotype effects and genotype × marijuana misuse interaction effects on WM volumes. rs12199654-A homozygotes with marijuana abuse/dependence had significantly smaller total cerebral and lobar WM volumes.
|
22850347 |
2013 |
|
Gastric Adenocarcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to examine the inhibitory effects of PlGF knockdown on cell proliferation, apoptosis and migration through p38 mitogen-activated protein kinase (p38MAPK) and PI3K pathways in human adenocarcinoma gastric cell line (AGS).
|
26968576 |
2016 |
|
Malignant neoplasm of liver
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SATB1 expression and anoikis resistance were mainly regulated by HBV-encoded viral protein HBx through the activation of ERK and p38 MAPK signaling pathways to promote metastasis of liver cancer.
|
31147803 |
2019 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggest that HL may have a protective effect against memory impairment and prevent oxidative stress-induced injury via the regulation of UCP4 and CyclinD1 and the modulation of JNK and P38 MAPK signaling in AD.
|
30540319 |
2019 |