|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors.
|
9472046 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For image analysis, Feulgen-stained slides of tumor imprints and of disaggregated tumor cytospin preparations were evaluated with the CAS-200 image analyzer.
|
2047381 |
1991 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
CSE1L silence promoted apoptosis and inhibited cell proliferation and invasion.
|
31347172 |
2020 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
CSE1L downregulation triggered a reduction of cell proliferation and invasion ability, and an increase of apoptosis rate and cell sensitivity to ADR.
|
30144787 |
2018 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of the YPEL3 gene inhibited the proliferation, migration, and invasion of the HT-29 and HCT-8 colonic adenocarcinoma cells, and inactivated the Wnt/β-catenin signaling pathway; treatment with the Wnt agonist, CAS 853220-52-7, reduced the inhibitory effects of YPEL3 overexpression on proliferation, migration, and invasion in vitro.
|
29988027 |
2018 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells.
|
28808245 |
2017 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
|
23806821 |
2013 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Expression profiling of ovarian cancer cells after CSE1L silencing showed that CSE1L was required for the expression of genes promoting invasion and metastasis.
|
23948303 |
2013 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) acts as a scaffold protein and belongs to a family of CAS (Crk-associated substrate) that regulates protein complexes controlling invasion and differentiation.
|
22447485 |
2012 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer.
|
22450763 |
2012 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Cas proteins mediate integrin-dependent signals at focal adhesions, regulating cell invasion and survival; at least one family member, HEF1, regulates mitosis.
|
18256281 |
2008 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Furthermore, the localization of CAS is mainly restricted in the nucleus in the lesions of normal human testicular tissue and cancer adjacent normal testicular tissue.
|
31140031 |
2019 |
|
Tuberculosis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In Kampala, Uganda, there are three sub-lineages of M. tuberculosis lineage 3 that cause disease of comparable severity with CAS-Dehli as the most prevalent.
|
31498808 |
2019 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Available associated information on gender (n = 18,944), age (n = 16,968), drug resistance (n = 19,606), and HIV serology (n = 2673), allowed to draw some important conclusions on TB geo-epidemiology; e.g. a positive correlation exists between certain Mycobacterium tuberculosis lineages (such as CAS and Beijing) and drug resistance (p-value<.001), while other lineages (such as LAM, X, and BOV) are more frequently associated with HIV-positive serology (p-value<.001).
|
30593925 |
2019 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
CAS-viewer: web-based tool for splicing-guided integrative analysis of multi-omics cancer data.
|
29697367 |
2018 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to determine in vitro, the susceptibility patterns of M. tuberculosis Uganda family compared with Beijing and Delhi/CAS, other M. tuberculosis sub-lineages that also circulate in Uganda but are not as prevalent.
|
27097724 |
2016 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The most frequent superfamily of M tuberculosis in clinical isolates was Delhi/CAS (142, 30.3%) followed by NEW-1 (127, 27%).
|
25340935 |
2015 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
|
23806821 |
2013 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The cellular apoptosis susceptibility gene CAS/CSE1L is overexpressed in cancer, although it was originally identified as a gene that renders cells vulnerable to apoptotic stimuli.
|
22389439 |
2012 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Moreover, high congruence between the MIRU-VNTR-based and spoligotyping-based strain groupings suggests that CAS, EAI and Beijing are the predominant strain lineages in the Mumbai TB patient population.
|
22321730 |
2012 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The most frequent M. tuberculosis lineage was Lineage 3 (CAS/Delhi) with 106 isolates (40.6%), followed by Lineage 2 (East-Asian lineage, includes Beijing genotype) with 84 isolates (32.2%), Lineage 4 (Euro-American lineage) with 41 (15.7%) isolates, and Lineage 1 (Indo-Oceanic lineage) with 30 isolates (11.5%).
|
23300635 |
2012 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The cellular apoptosis susceptibility (CSE1L/CAS) protein is a microtubule-associated protein that is highly expressed in cancer.
|
20688056 |
2010 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
PPM1H controls cell cycle and proliferation of cancer cells potentially through dephosphorylation of CSE1L and might be a new target of anticancer drugs.
|
18059182 |
2008 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Two STs; ST26 (CAS_Delhi) and ST1 (Beijing) represented 36.1% of the total M. tuberculosis population in eastern Uttar Pradesh, North India.
|
18372222 |
2008 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The observed distribution of genotypes shows that principal genetic group 1 strains (EAI, Beijing, CAS, Afri, "Manu") is high (35.4%) suggesting an ancient evolutionary history of tuberculosis in Madagascar, in relation to the origin of peopling and the demographic history.
|
16168940 |
2005 |