|
Hypertensive disease
|
0.130 |
Biomarker
|
group |
BEFREE |
These findings support that haploinsufficiency of ARHGAP42 leads to an age-dependent hypertension.
|
30903111 |
2019 |
|
Hypertensive disease
|
0.130 |
Biomarker
|
group |
BEFREE |
Moreover, these findings provide a potential mechanism for a hypertensive locus recently identified within arhgap42 and provide a foundation for the future development of innovative hypertension therapies.
|
24335996 |
2013 |
|
Hypertensive disease
|
0.130 |
GeneticVariation
|
group |
BEFREE |
Our analysis of a well-characterized cohort of untreated borderline hypertensive patients suggested that ARHGAP42 genotype has important implications in regard to hypertension risk.
|
28112683 |
2017 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The overexpression and silence experiments of ARHGAP42 were performed in NPC cell lines using siRNA and expressive plasmid for evaluating cancer cell migration and invasion in vitro.
|
29936709 |
2018 |
|
Diarrhea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The children were randomly divided into the study's two treatment groups: three days of the oral administration of (i) a probiotics formula containing both <i>Bifidobacterium longum</i> BORI and <i>Lactobacillus acidophilus</i> AD031 (<i>N</i> = 28); or (ii) a placebo (probiotic-free skim milk, <i>N</i> = 29) and the standard therapy for diarrhea.
|
28813007 |
2017 |
|
Rotavirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The Efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 Probiotic Treatment in Infants with Rotavirus Infection.
|
28813007 |
2017 |
|
Malignant neoplasm of nasopharynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the silence of uc010rul resulted in ARHGAP42 expression decrease and significant inhibition of nasopharyngeal cancer cell migration and invasion.
|
29936709 |
2018 |
|
Niemann-Pick Disease, Type C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis indicated that NPC patients with highly ARHGAP42 expression were significantly associated with shorter metastasis-free survival.
|
29936709 |
2018 |
|
Cancer of Nasopharynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the silence of uc010rul resulted in ARHGAP42 expression decrease and significant inhibition of nasopharyngeal cancer cell migration and invasion.
|
29936709 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of ARHGAP42 resulted in significant inhibition of nasopharyngeal cancer cell migration and invasion in vitro, and the overexpression of ARHGAP42 showed the opposite effects.
|
29936709 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The overexpression and silence experiments of ARHGAP42 were performed in NPC cell lines using siRNA and expressive plasmid for evaluating cancer cell migration and invasion in vitro.
|
29936709 |
2018 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis indicated that NPC patients with highly ARHGAP42 expression were significantly associated with shorter metastasis-free survival.
|
29936709 |
2018 |
|
Hypertensive disease
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
21909115 |
2011 |
|
Hypertensive disease
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
|
29912962 |
2018 |
|
Blood Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.
|
30940143 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.
|
30940143 |
2019 |
|
Reticulocyte count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
|
27618452 |
2016 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |