CSF3, colony stimulating factor 3, 1440

N. diseases: 687; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002886
Disease: Anemia, Macrocytic
Anemia, Macrocytic
0.010 Biomarker disease BEFREE Neutrophil depletion limited blood loss in these mice, whereas exogenous administration of G-CSF in colitic wild-type mice caused macrocytic anemia. 31448510 2020
CUI: C0393642
Disease: Sepsis-Associated Encephalopathy
Sepsis-Associated Encephalopathy
0.010 Biomarker disease BEFREE Further studies on the roles of CCL11, CXCL10, and G-CSF may be especially important in terms of potential prevention of SAE between 4 and 24 h after the onset of sepsis. 31628962 2020
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.010 Biomarker disease BEFREE Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy. 31237127 2020
CUI: C3495798
Disease: Periodontal inflammation
Periodontal inflammation
0.010 Biomarker disease BEFREE G-CSF neutralization in periodontal inflammation could alleviate neutrophil infiltration and periodontal tissue destruction in experimental periodontitis. 31765840 2020
CUI: C3805247
Disease: Late onset neutropenia
Late onset neutropenia
0.010 Biomarker disease BEFREE Late-onset neutropenia (LON) requiring granulocyte colony-stimulating factor occurred more frequently in the ABOi group than in the ABOc group (4 vs. 0 patients) (P < 0.001). 31673829 2020
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.010 Biomarker phenotype BEFREE In conjunction with other therapies (salicylates, mesalamine sulfasalazine and prednisone), G-CSF ameliorates inflammatory bowel symptoms, but doses must be limited because it increases spleen size associated with abdominal pain. 30451720 2019
CUI: C0002726
Disease: Amyloidosis
Amyloidosis
0.010 Biomarker disease BEFREE An updated single center experience with plerixafor and granulocyte colony-stimulating factor for stem cell mobilization in light chain amyloidosis. 31566813 2019
CUI: C0002792
Disease: anaphylaxis
anaphylaxis
0.010 Biomarker phenotype BEFREE On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis. 31203715 2019
CUI: C0004610
Disease: Bacteremia
Bacteremia
0.010 GeneticVariation disease BEFREE The most common grades 3 to 4 adverse events of etoposide + G-CSF ± plerixafor were febrile neutropenia (69.35%), mucositis (51.62%), and bacteremia (20.97%).No fatal outcomes were observed. 30871977 2019
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
0.010 Biomarker disease BEFREE Below median G-CSF combined with elevated %CD90+ predicted BPD (positive predictive value = 100%). 31799226 2019
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.010 Biomarker disease BEFREE The control and treatment groups after MCAO received vehicle or G-CSF (G-CSF 50 μg/kg) 6, 24, and 48 h after brain ischemia. 31005633 2019
CUI: C0011175
Disease: Dehydration
Dehydration
0.010 AlteredExpression phenotype BEFREE Further, CsF3'H showed comparatively higher expression in floral tissues particularly stigma and its expression was significantly enhanced in response to UV-B, dehydration and salinity stress indicative of its role in stress. 31054842 2019
CUI: C0014060
Disease: Encephalitis, St. Louis
Encephalitis, St. Louis
0.010 AlteredExpression disease BEFREE In serum, G-CSF levels tended to be higher in jSLE patients (adjusted p-value = 0.06). 30563424 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.010 Biomarker phenotype BEFREE The effect of rutin and its mechanisms of action were evaluated in a model of hyperalgesia induced by G-CSF in mice. 30945072 2019
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia
0.010 Biomarker disease BEFREE In this retrospective study, we compared the incidence and duration of neutropenia and hospitalization in patients with HCL treated with cladribine followed by peg-filgrastim as primary prophylaxis versus daily filgrastim given "on demand" according to absolute neutrophil count (ANC). 31152919 2019
Leukoencephalopathy, Progressive Multifocal
0.010 Biomarker disease BEFREE To facilitate JCV elimination by accelerating immune reconstitution inflammatory syndrome (IRIS), all patients received subcutaneous filgrastim upon PML diagnosis and discontinuation of Nz; eight received plasma exchange (PLEX). 31139690 2019
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.010 AlteredExpression disease BEFREE In serum, G-CSF levels tended to be higher in jSLE patients (adjusted p-value = 0.06). 30563424 2019
CUI: C0029443
Disease: Osteomyelitis
Osteomyelitis
0.010 Biomarker disease BEFREE Importantly, we found that G-CSF level was significantly up-regulated in the serum from osteomyelitis patients infected by <i>S. aureus</i> Together, <i>S. aureus</i> infection might suppress the function of osteoblastic cells and induce progressive bone loss by up-regulating the level G-CSF, suggesting a therapeutic potential for G-CSF neutralization in combating bone loss in <i>S. aureus</i> osteomyelitis. 31175224 2019
CUI: C0031117
Disease: Peripheral Neuropathy
Peripheral Neuropathy
0.010 Biomarker group BEFREE Exposure-safety analyses supported the recommended brentuximab vedotin starting dose (1.2 mg/kg every 2 weeks), and effective management of peripheral neuropathy and neutropenia with dose modification/reduction and febrile neutropenia with granulocyte colony-stimulating factor primary prophylaxis. 31152605 2019
CUI: C0032269
Disease: Pneumococcal Infections
Pneumococcal Infections
0.010 AlteredExpression group BEFREE Secondly, we demonstrated that G-CSF transcript lung levels were significantly increased during pneumococcal infection. 31776393 2019
CUI: C0032302
Disease: Mycoplasma pneumonia
Mycoplasma pneumonia
0.010 AlteredExpression disease BEFREE Compared with sequential treatment with azithromycin alone, pidotimod combined with azithromycin significantly reduced the expression levels of IL-10 and G-CSF in serum of children with mycoplasma pneumonia, improved the curative effect and reduced the occurrence of adverse reactions, which has high application value in clinic. 31410140 2019
Purpura, Thrombotic Thrombocytopenic
0.010 Biomarker disease BEFREE However, there has been no report describing G-CSF-producing carcinoma combined with TTP. 31479879 2019
CUI: C0042384
Disease: Vasculitis
Vasculitis
0.010 Biomarker disease BEFREE When clinicians administer PEGylated granulocyte-colony stimulating factor (G-CSF) to cancer patients, drug-associated vasculitis should be suspected. 31391329 2019
CUI: C0085215
Disease: Ovarian Failure, Premature
Ovarian Failure, Premature
0.010 Biomarker disease BEFREE Thirty adult female rats were randomly subdivided into five groups: normal control (control), cyclophosphamide (CTX) plus subsequent PBS (POI + PBS), CTX plus subsequent PRP (POI + PRP), CTX plus subsequent G-CSF-mobilized PBMCs (POI + PBMCs), and CTX plus subsequent G-CSF-mobilized PBMCs combined with PRP (POI + PBMCs + PRP). 31034039 2019
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung
0.010 Biomarker disease BEFREE According to the autopsy findings, a diagnosis of primary lung squamous cell carcinoma producing G-CSF associated with TTP was made. 31479879 2019