|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
The aim was to examine the association of IL-23R with susceptibility to IBD in pediatric patients.
|
17309073 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Analysis accounting for Arg381Gln suggested that other loci within IL23R also influence IBD susceptibility.
|
17484863 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
We confirmed the findings that IL23R is a susceptibility gene for IBD with suggestive epistasis with the IBD5 locus in the CD population.
|
17508420 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We confirmed the findings that IL23R is a susceptibility gene for IBD with suggestive epistasis with the IBD5 locus in the CD population.
|
17508420 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The OR of the IL23R variant in our pediatric study is highly comparable with that reported previously in a non-Jewish adult inflammatory bowel disease case-control cohort (OR, 0.26).
|
17618837 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent whole genome scans suggest that a rare variant in the interleukin-23 receptor (IL23R) gene may actually protect against IBD.
|
17628615 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate the association between systemic lupus erythematosus (SLE) and polymorphisms in the interleukin-23 receptor (IL23R) gene, which have been previously found to be associated with two autoimmune diseases: inflammatory bowel disease and psoriasis.
|
17661912 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Eight IL23R gene polymorphisms (rs1,004,819, rs7,517,847, rs10,489,629, rs11,209,026, rs1,343,151, rs10,889,677, rs11,209,032, and rs1,495,965) were selected among the 10 most associated SNPs from the IBD study.
|
17678723 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
These findings, together with the previous results, suggest that the IL23R gene is one of the genetic factors implicated in the genetics of IBD in the general population.
|
17678845 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A recent study reported that a non-synonymous single nucleotide polymorphism (rs11209026, p.Arg381Gln) located in the IL23R gene is a protective marker for inflammatory bowel disease.
|
17877509 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
LHGDN |
No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The rs11209026 SNP in IL23R had a protective effect for IBD in the case-control analysis (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.10-0.37, P= 6.6E-09).
|
18047540 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
There was no evidence for epistasis between the IL17F p.His161Arg polymorphism and IBD-associated single nucleotide polymorphisms within the IL23R gene.
|
18088064 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Variants of the gene coding for interleukin 23 receptor (IL23R) have been confirmed to be associated with inflammatory bowel disease (IBD).
|
18164077 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
These data indicate that IL23R represents a novel shared susceptibility gene as its association with inflammatory bowel disease (IBD) has recently been verified.
|
18180107 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our findings also suggest that polymorphisms at IL23R and TNFRSF1A, and possibly HLA and TLR4, loci may account for phenotypic variation in IBD.
|
18338763 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Several promising associations between IBD and gene variants have been identified with the two best replicated so far being variants in the IL23R and ATG16L1 genes.
|
18341487 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent studies have shown association of the IL23R gene with inflammatory bowel disease, psoriasis and ankylosing spondylitis.
|
18368064 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
LHGDN |
This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
|
18383363 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
|
18383363 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The data show an association of both IL23R SNPs with overall IBD (statistically stronger, rs7517847; odds ratio [OR] = 0.79, 95% confidence interval [CI]: 0.67-0.94, minor allele frequencies: 0.355 in IBD patients versus 0.410 in controls; P = 0.005), somewhat stronger in Crohn's disease (OR = 0.74, 95% CI: 0.61-0.91) than in ulcerative colitis (OR = 0.84, 95% CI: 0.69-1.03).
|
18383521 |
2008 |