ADRA2A, adrenoceptor alpha 2A, 150

N. diseases: 102; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 GeneticVariation group BEFREE Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. 9631415 1998
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. 9631415 1998
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.010 GeneticVariation disease BEFREE This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE. 9855534 1998
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 Biomarker disease BEFREE We examined the hypothesis that ADHD + LD was associated with NE dysfunction at a molecular genetic level by testing for associations and additive effects between polymorphisms at three noradrenergic genes the adrenergic alpha2A receptor (ADRA2A), adrenergic alpha2C receptor (ADRA2C), and dopamine beta-hydroxylase (DBH) genes. 10334470 1999
CUI: C0751265
Disease: Learning Disabilities
Learning Disabilities 		0.010 GeneticVariation disease BEFREE We examined the hypothesis that ADHD + LD was associated with NE dysfunction at a molecular genetic level by testing for associations and additive effects between polymorphisms at three noradrenergic genes the adrenergic alpha2A receptor (ADRA2A), adrenergic alpha2C receptor (ADRA2C), and dopamine beta-hydroxylase (DBH) genes. 10334470 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 GeneticVariation group BEFREE The alpha(2A)-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. 10534508 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.520 Biomarker group CTD_human Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol. 10694191 2000
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.310 GeneticVariation disease BEFREE MspI identifies a biallelic polymorphism in the promoter region of the alpha(2A)-adrenergic receptor gene.Clinical Genetics 51, 129-130.) in 114 healthy control subjects and 55 patients with panic disorders. 10699231 2000
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.030 Biomarker phenotype BEFREE Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. 10909127 2000
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 GeneticVariation disease BEFREE We found no evidence for linkage of the ADRA2A gene with ADHD, using the transmission disequilibrium test in this set of families. 11304829 2001
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 11425914 2001
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. 11425914 2001
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.020 GeneticVariation disease BEFREE Subjects who were homozygous both GG in the G-261A polymorphism at the alpha(2A)AR locus and GlyGly in the Arg16Gly polymorphism at the beta2-adrenergic (beta2AR) receptor loci had significantly higher insulin sensitivity and lower catecholamine levels during mental stress than subjects with other genotypes. 11467765 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.040 GeneticVariation disease BEFREE The objective of the current study was to examine the potential impact of a C right arrow G substitution at position -1291 of the alpha2A-adrenergic receptor gene (ADRA2A) promoter on obesity and estimates of insulin, glucose, and lipid metabolism as well as circulating hormones, including salivary cortisol in 284 unrelated Swedish men born in 1944. 11886485 2002
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 GeneticVariation disease BEFREE Our results suggest that the ADRA2A gene might have a small effect on ADHD susceptibility or that this gene might modulate the severity of the disorder. 12815749 2003
CUI: C0424101
Disease: Inattention
Inattention 		0.060 GeneticVariation phenotype BEFREE Although no association with either MspI allele was observed through the haplotype relative risk (HRR) analysis, effects of the ADRA2A gene on inattention and combined (inattention + hyperactivity/impulsivity) symptom scores were detected (U = 222.5, z = 2.19, P = 0.03; and U = 208.5, z = 2.32, P = 0.02, respectively). 12815749 2003
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.050 GeneticVariation phenotype BEFREE Although no association with either MspI allele was observed through the haplotype relative risk (HRR) analysis, effects of the ADRA2A gene on inattention and combined (inattention + hyperactivity/impulsivity) symptom scores were detected (U = 222.5, z = 2.19, P = 0.03; and U = 208.5, z = 2.32, P = 0.02, respectively). 12815749 2003
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.030 GeneticVariation phenotype BEFREE Although no association with either MspI allele was observed through the haplotype relative risk (HRR) analysis, effects of the ADRA2A gene on inattention and combined (inattention + hyperactivity/impulsivity) symptom scores were detected (U = 222.5, z = 2.19, P = 0.03; and U = 208.5, z = 2.32, P = 0.02, respectively). 12815749 2003
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker phenotype RGD Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. 12946573 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.310 Biomarker disease CTD_human Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder. 14656453 2003
CUI: C0086769
Disease: Panic Attacks
Panic Attacks 		0.300 Biomarker disease CTD_human Heart rate and QT interval variability: abnormal alpha-2 adrenergic function in patients with panic disorder. 14656453 2003
CUI: C0438696
Disease: Suicidal
Suicidal 		0.010 GeneticVariation disease BEFREE The purpose of this study was to test the hypothesis that genetic variants of the alpha(2A) adrenergic receptor gene are implicated in suicide and/or have a modulatory effect on personality traits that are believed to mediate suicidal behavior. 15006432 2004
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 GeneticVariation disease BEFREE This study supports the hypothesis that an allele of the ADRA2A gene is associated and linked with the ADHD combined subtype and suggests that the DraI polymorphism of ADRA2A is linked to a causative polymorphism. 15520832 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 GeneticVariation disease BEFREE The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.530 Biomarker disease PSYGENET The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. 16333651 2006