Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.
|
8892957 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a previous study we reported that constitutive activating point mutations of the ACTH receptor (ACTH-R) gene, a member of the G protein-coupled receptor superfamily, were not present in hormone-secreting and nonsecretory adrenocortical neoplasms.
|
9284742 |
1997 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.030 |
Biomarker
|
disease |
BEFREE |
The chemokine receptor, CCR-5, a G protein-coupled receptor (GPCR) which mediates chemotactic responses of certain leukocytes, has been shown to serve as the primary co-receptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1).
|
9303305 |
1997 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.
|
9367686 |
1997 |
Malignant neoplasm of breast
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.
|
9367686 |
1997 |
Hereditary Sensory Autonomic Neuropathy, Type 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.
|
10087195 |
1999 |
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
|
10094932 |
1999 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.030 |
Biomarker
|
disease |
BEFREE |
The chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the principal coreceptors for T cell line-tropic and macrophage-tropic HIV-1 isolates, respectively.
|
10358771 |
1999 |
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis.
|
10364352 |
1999 |
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptor.
|
10438939 |
1999 |
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
|
10537322 |
1999 |
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
|
10537322 |
1999 |
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
|
10537322 |
1999 |
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While vCYC (AKS 6 of 6; CKS 3 of 3), vMIP-I (AKS 5 of 6, CKS 3 of 3), vBCL2 (AKS 6 of 6; CKS 3 of 3), and vIRF1 (AKS 5 of 6, CKS 3 of 3) transcripts were detected in both AKS and CKS, vGCR and HIV-1 Tat were expressed only in AKS samples (vGCR: AKS 3 of 6, CKS 0 of 3; Tat: AKS 4 of 6, CKS 0 of 3). vMIPII, vCBP, and vIL6 expression were not detected in any KS samples.
|
10662620 |
2000 |
Atypical Ductal Breast Hyperplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This novel mutation in the CaSR gene provides the first known examples of a large naturally occurring deletion within a G-protein-coupled receptor's carboxylterminal-tail and of a homozygous, affected individual with ADH.
|
10770217 |
2000 |
Autosomal dominant hypocalcemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Autosomal dominant hypocalcemia (ADH) can result from heterozygous missense activating mutations of the calcium-sensing receptor (CaSR) gene, a G-protein-coupled receptor playing key roles in mineral ion metabolism.
|
10770217 |
2000 |
Obesity
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice.
|
10903341 |
2000 |
Aortic Valve Insufficiency
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally beta-AR signalling is strongly regulated by members of the G-protein-coupled receptor kinase family (GRKs), the best known of which is beta-adrenergic receptor kinase 1 (beta-ARK1). beta-ARK1 mRNA, protein level and enzymatic activity is increased in heart disease, further contributing to an attenuation in beta-AR signalling.
|
11027943 |
2000 |
Autosomal dominant retinitis pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the ability of triplex-forming oligodeoxyribonucleotides (TFOs) to inhibit genes responsible for dominant genetic disorders, we used two TFOs to block expression of the human rhodopsin gene, which encodes a G protein-coupled receptor involved in the blinding disorder autosomal dominant retinitis pigmentosa.
|
11058128 |
2000 |
Leukemia, T-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Isolated mRNAs expressed differentially between the two types of ATL include a T-cell differentiation antigen (MAL), a lymphoid-specific member of the G-protein-coupled receptor family (EBI-1 / CCR7), a novel human homologue to a subunit (MNLL) of the bovine ubiquinone oxidoreductase complex, and a human fibrinogen-like protein (hpT49).
|
11092974 |
2000 |
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Isolated mRNAs expressed differentially between the two types of ATL include a T-cell differentiation antigen (MAL), a lymphoid-specific member of the G-protein-coupled receptor family (EBI-1 / CCR7), a novel human homologue to a subunit (MNLL) of the bovine ubiquinone oxidoreductase complex, and a human fibrinogen-like protein (hpT49).
|
11092974 |
2000 |
Malignant neoplasm of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer.
|
11118034 |
2000 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer.
|
11118034 |
2000 |
Retinoblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Potential G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) mediation of homologous desensitization of corticotropin-releasing factor type 1 (CRF1) receptors was investigated in human retinoblastoma Y-79 cells.
|
11247813 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the present findings also emphasize the importance of this G protein-coupled receptor in the development of KSHV-related neoplasias.
|
11289142 |
2001 |