Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study evaluates the utility of autopsy lung for studies of gene expression and examines the hypothesis that increased expression of beta 2 AR mRNA in peripheral lung underlies the increased receptor number reported in central airways in fatal asthma. beta 2AR mRNA levels have been quantitated using the ribonuclease protection assay on RNA from peripheral lung obtained both at autopsy and thoracotomy from subjects with normal lungs as well as subjects with asthma or chronic obstructive pulmonary disease (COPD).
|
7680566 |
1993 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequencies of three polymorphisms at amino acid positions 16, 27, and 164 of the beta(2)-adrenoceptor (beta(2)-AR) gene and their effects on COPD patients.
|
11713125 |
2001 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD.
|
15596681 |
2004 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The aim of this study was to examine the associations between the beta ( 2 ) AR polymorphisms and risks of asthma, chronic obstructive pulmonary disease (COPD) and respiratory symptoms in a sample of adults.
|
16946993 |
2006 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Enhancing these study design factors will provide high-quality evidence regarding the biological and clinical importance of beta(2)-adrenoceptor pharmacogenomics in asthma and COPD.
|
17714090 |
2007 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD.
|
17890463 |
2007 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of the beta2-adrenergic receptor (ADRB2) genotype in patients with chronic obstructive pulmonary disease (COPD) is unclear.
|
18667995 |
2008 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Clinical consequences of ADRbeta2 polymorphisms.
|
18303970 |
2008 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated immediate bronchodilator response and lung function responses following a 12-week treatment with a long-acting beta(2) agonist combined with a steroid inhaler in patients with COPD with various ADRB2 genotypes.
|
18758858 |
2009 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p=0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype.
|
18789663 |
2009 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SERPINA1 p.V213A polymorphism was found associated with DB risk while the ADRB2 p.G16R is a risk factor for severe COPD in smokers.
|
19747908 |
2010 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine the association of ADRB2 polymorphisms and preferential BDR to β2-agonists and anticholinergics in patients with COPD.
|
21881540 |
2011 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygous haplotype for the CysGlyGln of β2AR may be associated with susceptibility to desensitization to LABA in patients with COPD.
|
22526864 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).
|
22075484 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, a meta analysis was done to investigate the effect of polymorphisms in the β2-adrenergic receptor (ADRB2) gene on the risk of COPD and lung function.
|
22884155 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several once-daily β(2)-AR agonists or ultra-long-acting β(2)-AR-agonists (LABAs), such as indacaterol, olodaterol, and vilanterol, are already in the market or under development for the treatment of COPD and asthma, but current recommendations suggest the use of LABAs only in combination with an inhaled corticosteroid.
|
22611179 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An increase of the ADRB2 genes expression was demonstrated in patients with severe asthma and COPD as compared with patients with mild and moderate disease.
|
22192964 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analysis showed little evidence for the association between these ADRB2 variants and indacaterol response, suggesting that ADRB2 genetic variation is unlikely to have a major role in differential response to indacaterol treatment in COPD patients.
|
22158330 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the objective of this study was to determine the role of β2ARs in EPCs function and, if this role is altered, in the COPD population.
|
23448263 |
2013 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We did a prespecified analysis of the ADRB2 polymorphisms Arg16Gly and Gln27Glu within the 1 year randomised, double-blind, double-dummy, parallel-group Prevention Of Exacerbations with Tiotropium in COPD (POET-COPD) trial, comparing the effects of treatment with tiotropium or salmeterol on exacerbations in 7376 patients with COPD.
|
24461901 |
2014 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The exploration of these mechanisms may contribute to the optimization of β2-AR target therapy in chronic obstructive pulmonary disease.
|
24905583 |
2014 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, we found that the rare Thr164Ile polymorphism in ADRB2 was associated with reduced lung function and risk of COPD, whereas the more common Gly16Arg and Gln27Glu were not.
|
25186548 |
2014 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eighty-two patients with COPD and 17 healthy smokers were recruited and screened for ADRb2 (T164I and R175R), for CHRM2 (rs1824024) and for CHRM3 (-513C/A and -492C/T).
|
26633752 |
2016 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of COPD.
|
28093224 |
2017 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Salmeterol is a long-acting β2-adrenergic receptor agonist used to treat chronic obstructive pulmonary disease.
|
28398147 |
2017 |