|
gliosarcoma
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
|
9766669 |
1998 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
|
21716162 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues.
|
28954402 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
These alterations induced by Type II diabetes in the endogenous pathway (CYP450) of arachidonic acid metabolism may increase the risk for cardiovascular disease by disrupting the fine equilibrium between cardioprotective (CYP2J/CYP2C-generated) and cardiotoxic (CYP4A/CYP4F-generated) metabolites of arachidonic acid.
|
29023376 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
CYP2C enzymes are responsible for the oxidative metabolism of a diverse number of drugs for the treatment of type 2 diabetes mellitus, a severe metabolic disorder with high prevalence.
|
21939641 |
2011 |
|
Epilepsy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
|
8874828 |
1996 |
|
Epilepsy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
|
9333104 |
1997 |
|
Epilepsy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We aimed to evaluate the association of non-response to antiepileptic pharmacotherapy with the frequency of variant alleles in the drug transporter genes ABCB1 and ABCC2 or in the CYP2C locus in young patients with epilepsy and an independent cohort of adults with drug-refractory epilepsy.
|
19415824 |
2009 |
|
Sudden infant death syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The amount of RNA encoding CYP2C9 (4.4x control), 2C8 (2.5x) and 2C18 (2.3x) was markedly higher in SIDS than in age-matched children and would suggest a transcriptional activation of CYP2C gene expression.
|
9864383 |
1999 |
|
Sudden infant death syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The precocious expression of CYP2C in SIDS could result in a higher production of epoxyeicosatrienoic acids in the neonate, believed to act as relaxant of pulmonary smooth muscles.
|
8687505 |
1996 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The first group contained 11 CYPs, including the CYP2C and CYP4F families, that showed decreased expression in parallel with progression of HCV-infected liver to HCC with less differentiation.
|
16077914 |
2005 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the prognostic value of CYP2C subfamily gene expression levels with HCC prognosis.
|
29479826 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CYP2C and IL-6 expression in breast cancer.
|
14759713 |
2004 |
|
Cholestasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The constitutive androstane receptor (CAR)/pregnane X receptor (PXR)-CYP2B/CYP2C axis is activated in DKO livers but not in other cholestasis models.
|
29718219 |
2018 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study indicated that the presence of UC decreases CYP2C expression levels in the liver, thereby delaying the metabolism of CYP2C substrates, including phenytoin, and increasing blood concentrations of these substrates.
|
29130833 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of CYP2C or CYP2J2 have a pathologic impact on coronary artery diseases.
|
21476972 |
2011 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our preliminary results demonstrate that polymorphisms of genes encoding CYP2C subfamily represent potential genetic markers of CHD susceptibility.
|
28687336 |
2017 |
|
Patent ductus arteriosus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CYP2C polymorphism was not associated with PDA response to ibuprofen and this factor appears not appropriate to optimize the ductal closure rate by modulating ibuprofen dosing strategy.
|
20808793 |
2010 |
|
Dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Surprisingly, treatment with G120RhGH failed to antagonize the effects of infusions or injections of hGH in hypophysectomized (Hx) rats and had little effect on hepatic GH-sensitive CYP2C transcripts in GH-deficient dwarf (dw) rats.
|
8593788 |
1996 |
|
Toxic Epidermal Necrolysis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further multicenter studies and large prospective observational studies are, however, still required to determine the influence of CYP2C*3 on blood levels of PHT and its metabolites, and their association with SJS/TEN.
|
29274302 |
2018 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The first group contained 11 CYPs, including the CYP2C and CYP4F families, that showed decreased expression in parallel with progression of HCV-infected liver to HCC with less differentiation.
|
16077914 |
2005 |
|
Peptic Ulcer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.
|
23267857 |
2013 |
|
Schwartz-Jampel Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further multicenter studies and large prospective observational studies are, however, still required to determine the influence of CYP2C*3 on blood levels of PHT and its metabolites, and their association with SJS/TEN.
|
29274302 |
2018 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, genes of CYP2C subfamily are important genetic determinants of susceptibility to essential hypertension in Russians.
|
28513222 |
2017 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of CYP2C gene expression in samples of lung cancer was significantly higher than in normal lung tissue, but the level of CYP3A4 gene expression was not.
|
11488523 |
2001 |