|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men.
|
16580401 |
2006 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure.
|
16275261 |
2005 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Together with published data, our analysis of DAZ gene copy suggested that the contribution of the different deletions to male infertility varies: only partial AZFc deletions removing DAZ1/DAZ2 seem to be associated with spermatogenic impairment, whereas those removing DAZ3/DAZ4 may have no or little effect on fertility.
|
15744033 |
2005 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure.
|
16275261 |
2005 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Deletions of the AZFc region in Yq11.2, which include the DAZ gene family, are responsible for most cases of male infertility and were associated with severe oligozoospermia and also with a variable testicular pathology.
|
15347736 |
2004 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
LHGDN |
Our findings suggest that the loss of only some copies of DAZ is sufficient to lead to severe male infertility, but it is not a frequent finding in cryptorchid men.
|
15066457 |
2004 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that the loss of only some copies of DAZ is sufficient to lead to severe male infertility, but it is not a frequent finding in cryptorchid men.
|
15066457 |
2004 |
|
Oligospermia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The transcript ratios for BOULE, DAZL, and DAZ were significantly decreased in tissues with spermatogenic failure (hypospermatogenesis, maturation arrest, and Sertoli cell-only).
|
15066460 |
2004 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To uncover the functional contribution of DAZ to human spermatogenesis, a DAZ gene copy-specific deletion analysis was previously established and showed that DAZ1/DAZ2 deletions associate with oligozoospermia.
|
15347736 |
2004 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.
|
12085101 |
2002 |
|
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Deletion of RBM and DAZ in azoospermia: evaluation by PRINS.
|
11807882 |
2002 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Twelve of 101 patients (12%) with the AZFc/DAZ microdeletion were found, including 8 with azoospermia (11%) and 4 with severe oligozoospermia (14.3%), and 1 patient had a AZFb and AZFc/DAZ double deletion.
|
11930664 |
2002 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The deleted-in-azoospermia (DAZ) gene family constitutes the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility, being deleted in about 10% of azoospermic and severely oligozoospermic subjects.
|
11883873 |
2002 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Microdeletion on the Y chromosome, especially at its AZFc/DAZ regions, may be a major cause of azoospermia and severe oligozoospermia leading to male infertility in China.
|
11930664 |
2002 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
LHGDN |
[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].
|
11688365 |
2002 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells.
|
12039700 |
2002 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Twelve of 101 patients (12%) with the AZFc/DAZ microdeletion were found, including 8 with azoospermia (11%) and 4 with severe oligozoospermia (14.3%), and 1 patient had a AZFb and AZFc/DAZ double deletion.
|
11930664 |
2002 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
With these diagnostic tools, 63 DNA samples from men with idiopathic oligozoospermia and 107 DNA samples from men with proven fertility were analysed for the presence of the complete DAZ gene locus, encompassing the four DAZ gene copies.
|
11870237 |
2002 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Such deletions determine azoospermia more frequently than severe oligozoospermia and involve especially the AZFc region including the DAZ gene family.
|
11294825 |
2001 |
|
Azoospermia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To investigate the expression of deleted in azoospermia (DAZ), RNA-binding motif (RBM), and chromodomain y1 (CDY1) genes in the testes of men with azoospermia with variable histopathologies.
|
11163833 |
2001 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility.
|
11263480 |
2001 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Such deletions determine azoospermia more frequently than severe oligozoospermia and involve especially the AZFc region including the DAZ gene family.
|
11294825 |
2001 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Blood, spermatozoa or testicular cells from 47 men (27 oligozoospermia, 20 azoospermia), including six Y-deleted patients, were screened for mosaicism using double target fluorescence in-situ hybridization (FISH) with Y centromeric and deleted in azoospermia (DAZ) gene-specific probes.
|
10908277 |
2000 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DAZ (Deleted in AZoospermia) gene family was isolated from a region of the human Y chromosome long arm that is deleted in about 10% of infertile men with idiopathic azoospermia.
|
10819768 |
2000 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This procedure could be particularly useful in screening for the DAZ locus in the diagnostic workup of nonobstructive azoospermia and severe oligoasthenoteratozoospermia.
|
10685522 |
2000 |