Cryptorchidism
|
0.140 |
Biomarker
|
disease |
BEFREE |
A total of 146 cryptorchid and 140 infertile patients without a history of cryptorchidism were screened with a sequence tagged site plus/minus method and further confirmed and characterized by CDY1/DAZ gene dosage and copy analysis.
|
17609244 |
2007 |
Cryptorchidism
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
The frequency of complete AZF deletions was similar in idiopathic (13.3%) and cryptorchid men (11.6%), but partial DAZ deletions were found only in infertile subjects without cryptorchidism (7.1%).
|
15066457 |
2004 |
Cryptorchidism
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR) amplification of 51 DNA loci encompassing all of the regions for azoospermia factor (AZF) of the Y chromosome, including the deleted in azoospermia (DAZ) and ribonucleic acid-binding motif (RBM) genes, were examined for microdeletions in 10 PWS males with cryptorchidism and 20 healthy control male subjects.
|
11869370 |
2002 |
Cryptorchidism
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether deletions of the DAZ (deleted in azoospermia) gene, abnormal karyotypes or hypogonadotropic hypogonadism (HH) were demonstrable in infertile men who had undergone surgery in childhood for cryptorchidism with a simultaneous testicular biopsy that demonstrated no or almost no germ cells.
|
9880685 |
1998 |
Cryptorchidism
|
0.140 |
Biomarker
|
disease |
HPO |
|
|
|
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
Male infertility
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility.
|
28521575 |
2018 |
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
|
27739146 |
2016 |
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
|
27739146 |
2016 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively.
|
26149076 |
2015 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%).
|
26232607 |
2015 |
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The purpose of this study was to determine the association of AZFc subdeletions (gr/gr, b1/b3 and b2/b3) and deletion of DAZ and CDY1 gene copies with male infertility
|
26149076 |
2015 |
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male.
|
26232607 |
2015 |
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively.
|
26149076 |
2015 |
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%).
|
26232607 |
2015 |
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy.
|
24878370 |
2014 |
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy.
|
24878370 |
2014 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The AZFc(azoospermia factor c)/DAZ (deleted in azoospermia) duplications might underlie the susceptibility of Y-hg K* to spermatogenic impairment.
|
23696539 |
2013 |
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of DAZ gene copies in AZFc microdeletions suggests that the contribution of the different deletions to male infertility varies.
|
23512232 |
2013 |
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Transmission of DAZ (Deleted in Azoospermia) microdeletion is one of the major concerns for oligo and severe oligozoospermia patients.
|
22648284 |
2012 |
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although AZFc is deleted in azoospermia or oligozoospermia, no definitive conclusion has been drawn for the role of partial AZFc deletions to spermatogenic failure.
|
20823911 |
2011 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
gr/gr deletions were analyzed by using markers sY1291, sY1191 and sY1197 and by investigating the presence of single nucleotide variants (SNV) in DAZ and CDY1 genes in patients with azoospermia (n = 44), cryptozoospermia (n = 51) or severe oligozoospermia (n = 92).
|
18326516 |
2008 |
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
gr/gr deletions were analyzed by using markers sY1291, sY1191 and sY1197 and by investigating the presence of single nucleotide variants (SNV) in DAZ and CDY1 genes in patients with azoospermia (n = 44), cryptozoospermia (n = 51) or severe oligozoospermia (n = 92).
|
18326516 |
2008 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men.
|
16580401 |
2006 |