|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E (APOE) E4, apolipoprotein B-100 (APOB) Q3611 allele, the angiotensin converting enzyme (ACE) deletion (D) allele and glycoprotein IIIa (GP3A) P33 mutant allele are reported to predispose to early-onset coronary heart disease (CHD).
|
10463820 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, a cross-sectional analysis was performed to evaluate the potential relationship between the ACE I/D genotypes and the LV mass index in 289 non-insulin-dependent diabetes mellitus (NIDDM) subjects without known coronary artery disease.
|
10371375 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, our study suggests that genetic polymorphisms of angiotensin-converting enzyme insertion/deletion are associated with in-stent restenosis in coronary artery disease patients following coronary stenting.
|
28196432 |
2017 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In association analysis the ACE genotype frequencies of probands with CHD did not differ from those of healthy controls.
|
11427204 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have tested the hypothesis that the angiotensin-converting enzyme (ACE) DD genotype and the angiotensin II type I receptor (AT1R) gene C allele represent the common link between microalbuminuria and coronary heart disease.
|
9351388 |
1997 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A multiple logistic regression analysis introducing the typical risk factors for CHD (age, gender, smoking, BMI > 26 kg/m 2, LDL elevation, HbA1c > 7 %) could not identify the ACE gene I/D-polymorphism as an independent risk factor for CHD (p = 0.87).
|
12669270 |
2003 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The presence of deletion (D) allele in angiotensin converting enzyme (ACE) gene polymorphism is associated with coronary artery disease.
|
17285438 |
2007 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present results show that subjects with the ACE/DD genotype are not at increased risk for CHD because of insulin resistance, relative hyperglycemia and hyperinsulinemia, or a dyslipidemia characterized by a high triglyceride and low HDL cholesterol concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
|
7773733 |
1995 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression.
|
22683751 |
2012 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has been suggested that the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene is an independent risk factor for coronary artery disease, but its relation to stroke has not yet been proven.
|
8784123 |
1996 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion-deletion (ID) polymorphism interacts with pravastatin to modify the risk of coronary heart disease (CHD) and other cardiovascular end points in a large clinical trial.
|
17174637 |
2007 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease.
|
20655894 |
2010 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD).
|
15635071 |
2005 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By contrast, there was no evidence of a significant increase in the risk of CHD or myocardial infarction among individuals with ACE DD.
|
7783537 |
1995 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ACE insertion/deletion gene polymorphism is associated neither with the prevalence nor the extent of coronary artery disease, nor with myocardial infarction in this relatively large sample of Caucasian men and women.
|
10462466 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our report indicates the increased risk of coronary artery disease in the presence of ACE DD and AT1R CC genotypes independent of other risk factors, in Italian patients.
|
10731400 |
2000 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.
|
21567207 |
2011 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ACE/ID polymorphism seems to be a potent risk factor of coronary heart disease in subjects formerly considered to be at low risk according to common criteria.
|
1328889 |
1992 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis assessing the influence of the ACE polymorphism on disease susceptibility demonstrated significant odds ratios in individuals with the DD genotype for coronary heart disease, myocardial infarction and both diabetic and nondiabetic renal disease.
|
10391391 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, attention has been focused on the correlation between coronary artery disease and genetic factors, such as ACE gene polymorphism or the gene polymorphism for the IIIa-moiety of the platelet fibrinogen receptor IIb-IIIa.
|
9519344 |
1998 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Many authors have reported an association between the angiotensin-converting enzyme (ACE)-D allele and coronary heart disease and other cardiovascular diseases.
|
10765051 |
2000 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis.
|
18504336 |
2008 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene.
|
12833177 |
2003 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease.
|
12747597 |
2003 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease.
|
25867352 |
2015 |