SLC30A8, solute carrier family 30 member 8, 169026

N. diseases: 63; N. variants: 23
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.040 AlteredExpression phenotype BEFREE Therefore, altered activity of ZnT-8 is expected to be associated with impaired glucose-induced insulin response and promote progression from glucose intolerance to diabetes. 19655390 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.040 GeneticVariation phenotype BEFREE To investigate the association of solute carrier family 30 member 8 (SLC30A8) rs13266634 C/T polymorphism with type 2 diabetes (T2DM), impaired glucose tolerance (IGT), and type 1 diabetes (T1DM). 21131091 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.040 Biomarker phenotype BEFREE Whereas insulin secretion from isolated islets is most often increased in mice inactivated for Slc30a8, null animals usually show impaired glucose tolerance and lowered circulating insulin. 25287711 2015
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.040 Biomarker phenotype BEFREE Blocking 5-HT synthesis in ZnT8-deficient mice restored adiposity, high-fat diet-induced obesity, and glucose intolerance. 30936149 2019