|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The breakthrough discovery that the common polymorphism in zinc transporter <i>SLC30A8</i>/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes.
|
29415457 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blood samples were obtained from 900 patients with age from 1 month to 25 years (median age 11.1 years) within 2 weeks of diabetes onset to test anti-islet autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA), insulinoma antigen (IA-2AA), the zinc transporter-8 (ZnT8AA), and islet-cell antibodies (ICA).
|
21138544 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we characterize an emerging role of ZnT-8 in diabetes and discuss potential mechanisms of its involvement in the etiology of both forms of diabetes.
|
19655390 |
2009 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 97 subjects with diabetes onset before age 25, a random C-peptide ≥0.1 ng/mL, and negative for all diabetes autoantibodies (GADA, IA-2, ZnT8, and IAA) were enrolled, after excluding 21 subjects with secondary diabetes or refusal to participate.
|
26059258 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Diabetes Autoimmunity Study in the Young (DAISY) followed prospectively for development of persistent IA (autoantibodies to insulin, GAD65, IA-2, or ZnT8 on at least two consecutive exams) and diabetes 1715 non-Hispanic white children at increased genetic risk for T1D.
|
22776074 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 31 Somali children ≤19 yr were treated for type 1 diabetes (T1D) at the University of Minnesota Masonic Children's Hospital and Children's Hospitals and Clinics of Minnesota underwent analysis of human leukocyte antigen (HLA) alleles (n = 30) and diabetes autoantibodies [glutamic acid decarboxylase (GAD65), islet antigen 2 (IA-2), zinc transporter 8 (ZnT8); n = 31].
|
26854192 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we summarize the literature about clinical aspects of ZnT8 in the pathogenesis of diabetes, and suggest that ZnT8 might play a different role between type 1 diabetes mellitus and type 2 diabetes mellitus.
|
27181765 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, Znt8 Arg-325 risk variant shows an enhanced inflammatory response upon LPS stimulation that might aggravate insulin resistance and the progression of diabetes cardiovascular complications.
|
30142362 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
It argues against ZnT8 autoimmunity arising from molecular mimicry and suggests a mechanistic link between the two major forms of diabetes.
|
18591387 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZnT8-ab positive patients had higher titre and more frequent occurrence of multiple diabetes-related autoantibodies than ZnT8-ab negative patients.
|
30465779 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZnT8-ab are associated with more acute diabetes onset.
|
29327148 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A registry-based group of 288 persistently autoantibody-positive (Ab(+)) offspring/siblings (aged 0-39 years) of known patients (Ab(+) against insulin, GAD, IA-2 and/or ZnT8) were typed for HLA-DQ, -A and -B and monitored from the first Ab(+) sample for development of diabetes within 5 years.
|
23712485 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The use of GADAs, IA-2As, and ZnT8As in combination allowed a stratification of clinical phenotype, with younger age of onset of diabetes and characteristics of more severe insulin deficiency (higher fasting glucose and A1C, lower BMI, total cholesterol, and triglycerides) in patients with all three markers, with progressive attenuation in patients with two, one, and no antibodies (all P(trend) < 0.001).
|
19808923 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8.
|
21198374 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
|
31676859 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
STZ treatment also suppressed expression of a wide range of genes linked with key β-cell functions or diabetes development, such as G6pc2, Slc2a2 (Glut2), Slc30a8, Neurod1, Ucn3, Gad1, Isl1, Foxa2, Vdr, Pdx1, Fkbp1b and Abcc8, suggesting global β-cell defects in STZ-treated islets.
|
23828045 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves' disease.
|
30783963 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, those with later onset type 1 diabetes had a modestly lower type 1 diabetes genetic risk score (0.268 vs 0.279; p < 0.001 [expected type 2 diabetes population median, 0.231]), a higher islet autoantibody prevalence (GAD-, islet antigen 2 [IA2]- or zinc transporter protein 8 [ZnT8]-positive) of 78% at 13 years vs 62% at 26 years of diabetes duration; (p = 0.02), and were less likely to identify as having type 1 diabetes (79% vs 100%; p < 0.001) vs those with young-onset disease.
|
30969375 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZnT8 was therefore proposed as a therapeutic target for diabetes, and recent genome-wide association studies identified polymorphisms in the ZNT8 gene conferring increased type 2 diabetes risk.
|
19095428 |
2009 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.
|
30392157 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of ZnT8A were measured in 2,239 British type 1 diabetic individuals diagnosed before age 17 years, with a median duration of diabetes of 4 years.
|
22526605 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In both animal models of diabetes, ZnT8 expression was remarkably downregulated in the early stage of diabetes.
|
21099260 |
2011 |