|
Phenylketonurias
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Another important role of the DTD enzyme is in the detection of Phenylketonuria disease.
|
31812741 |
2020 |
|
Thyroid associated opthalmopathies
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NQO1 levels were the lowest in the GO mouse model.
|
31705858 |
2020 |
|
Classical phenylketonuria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Another important role of the DTD enzyme is in the detection of Phenylketonuria disease.
|
31812741 |
2020 |
|
Dejerine-Sottas Disease (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At week 2, E2 administration to AOM/DSS-treated OVX mice attenuated the histological severity of colitis by decreasing the protein and/or mRNA levels of estrogen receptor alpha (ERα) and NF-κB-related mediators (i.e., COX-2, TNF-α, and IL-6) and by enhancing estrogen receptor beta (ERβ) and nuclear Nrf2 protein expression and the mRNA expression of related antioxidant enzyme genes (i.e., HO-1, GCLC, GCLM, and NQO1).
|
30981879 |
2019 |
|
Fanconi Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A marked increase in the expression levels of nuclear factor‑erythroid 2‑related factor 2 (Nrf2), NAD(P)H quinone dehydrogenase 1 and glutathione‑s‑transferase was detected in FA‑treated rats.
|
31173213 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Compared with the IUGR + 1% Arg or IUGR + 0.1% NCG lambs, the IUGR lambs had lower (P < 0.05) abundance of mRNA and protein abundance of glutathione peroxidase 1 (GPx1), catalase (CAT), superoxide dismutase 2 (SOD2), nuclear factor erythroid 2-related factor 2 (Nrf2), quinone oxidoreductase 1 (NQO1), heme oxygenase (HO-1), zonula occludens-1 (ZO-1), occludin, inducible NOS (iNOS), and epithelial NOS (eNOS).
|
31508643 |
2019 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Positive correlation was observed between the hepatic expression of NFE2L2 and NQO1 in the chronic HCV patients (p < 0.0001).
|
30929321 |
2019 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Azoreductase (AzoR) is an essential reductive enzyme which is closely associated with the intestinal disease such as ulcerative colitis (UC).
|
31362489 |
2019 |
|
nervous system disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We evaluated the following effects in male C57BL/6J mice with inflammatory pain induced by <i>complete Freund's adjuvant</i> or neuropathic pain caused by the chronic constriction of sciatic nerve: (1) the antinociceptive effects of UFP-512; (2) the effects of UFP-512 on the expression of Nrf2, heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1, phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), inducible nitric oxide synthase, DOR, and mitogen-activated protein kinases (MAPK) in the spinal cord of animals with inflammatory or neuropathic pain; (3) the antinociceptive effects of the coadministration of UFP-512 with the Nrf2 activator sulforaphane (SFN); and (4) the antidepressant effects of UFP-512 in animals with depressive-like behaviors associated with neuropathic pain.
|
30971925 |
2019 |
|
Renal fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with group N, the levels of FBG, renal index, 24‑h urine protein, BUN, SCr, LPO, MDA and Hyp were increased, whereas the levels of T‑AOC and SOD were decreased in group S. The structure of renal tissue was damaged, and the expression of Nrf2, HO‑1 and NQO1 were reduced, whereas the expression of TGF‑β1, Smad3, p‑Smad3 and collagen IV were increased in group S. Compared with group S, the aforementioned indices were improved in groups L and H. In conclusion, GEN exhibited reno‑protective effects in diabetic rats and its mechanisms may be associated with the inhibition of oxidative stress by activating the Nrf2‑HO‑1/NQO1 pathway, and the alleviation of renal fibrosis by suppressing the TGF‑β1/Smad3 pathway.
|
30431100 |
2019 |
|
Motor Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Unphosphorylatable NQO1 mutant displays more robust neuroprotective activity than WT NQO1 in suppressing reactive oxidative species and against MPTP-induced dopaminergic cell death, rescuing the motor disorders in both α-synuclein transgenic transgenic male and female mice elicited by the neurotoxin.
|
31358653 |
2019 |
|
Harlequin Fetus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, HI stress triggered an upregulation of Nrf-2 nuclear protein as well as some of its downstream anti-inflammatory genes such as HO-1 and NQO-1 in the cortex, while DOR activation further augmented such a protective reaction against HI injury.
|
30560518 |
2019 |
|
Secondary malignant neoplasm of female breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these results demonstrate that the NQO1/PKLR axis can promote the progression of BC by modulating glycolytic reprogramming and suggest that targeting NQO1 and its downstream effectors are promising therapeutic targets for preventing the BC progression.
|
30954648 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
The levels of antioxidant enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), were only increased in livers of RSV-treated mice compared with HF control mice.
|
31268397 |
2019 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NFE2L2 is associated with NQO1 expression and low stage of hepatic fibrosis in patients with chronic hepatitis C.
|
30929321 |
2019 |
|
Drug-Induced Liver Disease
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study.
|
30776144 |
2019 |
|
Enzyme inhibition disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The mechanisms and kinetics of enzyme inhibition of coumarin, aesculetin, umbelliferone, and scopoletin using the cell lysates as a source of NQO1 enzyme best fit with an uncompetitive inhibition model.
|
30584780 |
2019 |
|
DOSAGE-SENSITIVE SEX REVERSAL
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At week 2, E2 administration to AOM/DSS-treated OVX mice attenuated the histological severity of colitis by decreasing the protein and/or mRNA levels of estrogen receptor alpha (ERα) and NF-κB-related mediators (i.e., COX-2, TNF-α, and IL-6) and by enhancing estrogen receptor beta (ERβ) and nuclear Nrf2 protein expression and the mRNA expression of related antioxidant enzyme genes (i.e., HO-1, GCLC, GCLM, and NQO1).
|
30981879 |
2019 |
|
FRIEDREICH ATAXIA 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A marked increase in the expression levels of nuclear factor‑erythroid 2‑related factor 2 (Nrf2), NAD(P)H quinone dehydrogenase 1 and glutathione‑s‑transferase was detected in FA‑treated rats.
|
31173213 |
2019 |
|
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, there was no significant difference in the hepatic expression of GFER and NQO1 in relation to the progression of liver steatosis, inflammation and fibrosis.
|
30929321 |
2019 |
|
Chronic ulcerative colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe.
|
31362489 |
2019 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A marked increase in the expression levels of nuclear factor‑erythroid 2‑related factor 2 (Nrf2), NAD(P)H quinone dehydrogenase 1 and glutathione‑s‑transferase was detected in FA‑treated rats.
|
31173213 |
2019 |
|
Refractory anemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
An mRNA expression analysis revealed that CYP1A2 and CYP2E1 levels were decreased while those of NQO1, GPx, and GSTm1 increased after S. fruticosa and RA treatments.
|
28718679 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An mRNA expression analysis revealed that CYP1A2 and CYP2E1 levels were decreased while those of NQO1, GPx, and GSTm1 increased after S. fruticosa and RA treatments.
|
28718679 |
2018 |