Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma Hsp90α maintains also broad-spectrum for cancer subtypes, especially with 91.78% sensitivity and 91.96% specificity in patients with AFP-limited liver cancer.
|
31343810 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, analyzing data from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) and GSE14520 datasets revealed a significant correlation between MED15 expression and the tumor size (P=0.033), Barcelona Clinic Liver Cancer stage (P=0.031), α-fetoprotein levels (P=0.002) and metastasis risk (P=0.001).
|
29556287 |
2018 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer.
|
18194454 |
2008 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Even in clinical liver cancer samples, the expression of α-fetoprotein and Jagged1 showed significant correlation, and amplification of the copy number of Jagged1 was associated with Jagged1 mRNA expression and poor survival after liver cancer surgical resection.
|
27315779 |
2016 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effects of AFP-activated PI3K/Akt signaling pathway on cell proliferation of liver cancer.
|
24425104 |
2014 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The concentration of alpha-fetoprotein (AFP) rises greatly in patients with liver cancer and it is a challenge to construct a sensitive AFP detection method with wide range.
|
31761168 |
2020 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The prognostic value of PFS and OS-pPET-RadScore, Barcelona-Clinic Liver Cancer staging system and serum alpha-fetoprotein level was analyzed to predict PFS and OS in multivariate analysis.
|
29435123 |
2018 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Due to the small risk of liver cancer development, screening for liver cancer (especially HCC) is still recommended in HT1 patients using regular measures of α-fetoprotein and imaging.
|
28755188 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Univariate and multivariate analyses revealed the SHI was an independent predictor for overall survival and relapse-free survival, and prognostic for patients with negative α-fetoprotein and Barcelona Clinic Liver Cancer stage 0+A.
|
28769812 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
AFP is an important target in the treatment of liver cancer.
|
28554567 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serum AFP elevation by the infection of HBV and HCV is one of mechanisms which lead to hepatocarcinogenesis, and the antivirus intervening treatment of hepatitis is significant for the prognosis of liver cancer.
|
17465484 |
2007 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the immunogenicity of AFP is weak and it could induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes, AFP has attracted more attention in liver cancer immunotherapy.
|
29805966 |
2018 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, higher Child-Pugh class, alpha-fetoprotein levels over 400 kU/L, and later BCLC disease stages were each associated with higher mortality.
|
30309301 |
2018 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous studies indicated that targeted expression of therapeutic BikDD driven by a liver cancer-specific α-fetoprotein promoter/enhancer (eAFP) in the VISA backbone (eAFP-VISA-BikDD) significantly and specifically kills HCC cells in multiple orthotopic animal models.
|
26247632 |
2015 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cancer targeting gene-viro-therapy specific for liver cancer by α-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24.
|
21835849 |
2011 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
One-shot transfusion of hepatoma serum to naïve rats induced liver cancer development with gradual elevation of alpha-fetoprotein (AFP), but exosome-free hepatoma serum failed to induce AFP elevation.
|
31162867 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detection rate of AFP for liver cancer was 86.8%, and the exclusive diagnostic rate of AFP for hepatic FNH was 96.9%.
|
31646787 |
2020 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experiments were conducted in vivo using systemic administration of Adv-AFP-E1AdB and we observed tumor size reduction in nude mice having liver cancer.
|
11401492 |
2001 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Best performance was found for CEA in colorectal cancer (area under the curve=0.84, sensitivity=51.7% at 95% specificity vs. benign), CA19-9 in gallbladder/pancreatic cancer (AUC=0.85, sensitivity=60.6%) and AFP in liver cancer (AUC=0.87, sensitivity=68.4%).
|
28011514 |
2017 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The 20-week survival rate of DEN-induced liver cancer rats administered with oral 1,4-GL was increased from 45.0 to 70.0% with reduced carcinogenesis of the liver and significantly lowered serum α-fetoprotein level (14.28 ± 2.89 ng/mL vs. 18.56 ± 4.65 ng/mL, p = 0.012).
|
31070541 |
2018 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conductometric immunoassay of alpha-fetoprotein in sera of liver cancer patients using bienzyme-functionalized nanometer-sized silica beads.
|
30398232 |
2018 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PEG-PEI/Fe₃O₄ nanomagnetic fluid successfully transfected PEGFP-AFP-hTNFα into HepG2 cells and induced expression of hTNFα gene in the HepG2 cells, thus showing promise as a gene vector for liver cancer gene therapy.
|
21621154 |
2011 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-Fetoprotein (AFP), which is a serological marker of liver cancer, was used as a model analyte to test STA-AQ in an immunoassay.
|
21389603 |
2011 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway.
|
27925189 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a proof of concept, α-fetoprotein (AFP) was detected as a target, which is a biomarker of liver cancer.
|
28155925 |
2017 |