|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors.
|
7566118 |
1995 |
|
Parkinson Disease
|
0.600 |
Therapeutic
|
disease |
CTD_human |
ABT-431: the diacetyl prodrug of A-86929, a potent and selective dopamine D1 receptor agonist: in vitro characterization and effects in animal models of Parkinson's disease.
|
8558425 |
1996 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
|
9252189 |
1997 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia.
|
9247268 |
1997 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice.
|
9717839 |
1998 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus our results do not support a role for the DRD2 locus to develop PD.
|
10515181 |
1999 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further, DRD2 variants have been implicated in Parkinson's disease (PD) and in iatrogenically-induced movement disorders, as well as in certain migraineurs.
|
11256581 |
2000 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the DRD2 gene may influence the risk of developing PD, thus confirming that the DRD2 gene is a susceptibility locus for PD.
|
10634251 |
2000 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the hypothesis that a TaqI repeat fragment length polymorphism in the dopamine D2 receptor gene may be associated with PD.
|
11104188 |
2000 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Neuroprotective role of dopamine against hippocampal cell death.
|
11069974 |
2000 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This polymorphism may be in linkage disequilibrium with a mutation in DRD2 or a nearby gene that predisposes to drug-induced hallucinations which occur later in the course of idiopathic Parkinson's disease.
|
10739171 |
2000 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
When genotypes for DRD2 were considered in combination with genotypes for intron 13 of MAO-B, genotype combinations with high risk of Parkinson's disease were found; although the MAO-B/DRD2 interaction did not reach statistical significance after Bonferroni correction for multiple comparisons, these results are suggestive of a possible synergism between MAOB and DRD2 genes with respect to Parkinson's disease.
|
10990520 |
2000 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The -141C Ins/Del polymorphism of the dopamine D2 receptor gene is not associated with either migraine or Parkinson's disease.
|
11409701 |
2001 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested for gender-specific interactions between smoking and genetic polymorphisms of monoamine oxidase B (MAO-B) intron 13 (G or A allele), monoamine oxidase A (MAO-A) EcoRV (Yor N allele), and dopamine D2 recepor (DRD2) Taq1B (B1 or B2 allele) in a case-control study of 186 incident idiopathic Parkinson's disease (PD) cases and 296 age- and gender-matched controls.
|
12428723 |
2002 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
MGD |
Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice.
|
11864730 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease.
|
12722176 |
2003 |
|
Parkinson Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
No alteration in the level of dopamine D2 receptor or dopamine transporter mRNA was found in either lobule in patients with Parkinson's disease.
|
14622169 |
2003 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD.
|
15390060 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previously, we found a significant association between the dopamine D2 receptor gene polymorphism Taq IA and sudden onset of sleep in patients with Parkinson disease.
|
16124668 |
2005 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, alterations in RGS9-2 may be a key factor in the pathway leading from D2DRs to the side effects associated with the treatment both of psychoses and Parkinson's disease.
|
15728856 |
2005 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients Two hundred fifty patients with Parkinson disease were screened for the presence or absence of PDD following a short-term levodopa administration, and 215 subjects were available for further evaluations, including genotypic analysis of the CA dinucleotide short tandem repeat (CAn-STR) polymorphism located in the dopamine receptor D2 gene (DRD2).
|
15824260 |
2005 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated this effect in Parkinson's disease (PD) patients carrying the DRD2 TaqIA A1 allelic variant.
|
17147698 |
2007 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genotype combinations characterized by the presence of two variant genotypes on their corresponding loci revealed that four combinations of GSTT1 null and MnSOD(-9Val) or GST null and MAOB-G or CYP2E1*5B and MAO-B-AG or CYP2E1*5B and DRD2 (Taq1A-het) genotypes in the patients exhibited severalfold higher and significant association with risk to PD.
|
18327668 |
2008 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the DRD2 TaqIA polymorphism alone has no pivotal role for interindividual variability of dopaminergic requirement in PD.
|
18175338 |
2008 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
RGD |
Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.
|
18289173 |
2008 |