|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
High risk for essential hypertension in males conferred by g.15241A>G polymorphism in intron 3 of AGT gene.
|
22799745 |
2013 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hypertensive patients carrying the control genotype of rs2074192 (CC, OR = 2.37, 95% CI: 1.28-4.39) were associated with CAS ≥50%, while those carrying a high-EH-risk genotype of rs4240157 (OR = 2.62, 95% CI: 1.24-5.54), rs4646155 (OR = 2.44, 95% CI: 1.16-5.10), or rs4830542 (CC+CT, OR = 2.20, 95% CI: 1.03-4.69) were associated with atrial fibrillation (AF), larger left atrial diameter, and higher levels of renin-angiotensin-aldosterone system (RAAS) activation (renin and angiotensin I/II).
|
30542083 |
2019 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with mild-to-moderate essential hypertension in the HOMED-BP trial were randomly allocated to first-line treatment with a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB).
|
24192120 |
2013 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the contribution of variation in the angiotensinogen gene to the occurrence of essential hypertension is less than initially suspected, or may not be constant across populations.
|
7649545 |
1995 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
T+31C polymorphism of angiotensinogen gene and essential hypertension.
|
11230286 |
2001 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Many persons with essential hypertension carry a common "susceptibility gene" at the angiotensinogen locus (chromosome 1q4) identified using linkage studies in siblings, association studies, and in studies of preeclampsia and hypertension in pregnant women.
|
7988084 |
1994 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease.
|
11731937 |
2002 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT.
|
22570327 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
|
22974788 |
2012 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Angiotensinogen gene M235T and T174M polymorphisms in essential hypertension: relation with target organ damage.
|
9607382 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, our findings suggest that in white families with type 2 diabetes, there is no linkage between the degree of albumin excretion and ACE and AGN polymorphisms, whereas the latter is related to arterial hypertension, as previously found in patients without diabetes but with essential hypertension.
|
10585308 |
1999 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis with the aim of assessing the association of the angiotensin II type 1 (AT(1)) receptor gene A1166C polymorphism with essential hypertension in Chinese case-control studies.
|
20223791 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal.
|
9403549 |
1997 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review.
|
26607294 |
2016 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The issues confronting the genetic analysis of EH are discussed by drawing from our ongoing work along the hypothesis that molecular variants of the angiotensinogen gene may constitute inherited predispositions to the condition.
|
11037339 |
2001 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The hypothesis that genetic variation at the angiotensinogen locus impacts on individual susceptibility to develop essential hypertension has motivated a substantial body of research by us and many others.
|
17242300 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations.
|
14597849 |
2003 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of a polymorphism encoding threonine instead of methionine (M235T) has been associated not only with increased plasma angiotensinogen concentration but also with essential hypertension.
|
8593944 |
1996 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension.
|
11191642 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data provide evidence in favour of an association between hypertension and a genetic variant of AGT in human EHT, and a marked ethnic difference in the AGT gene.
|
7852920 |
1995 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.
|
8952609 |
1996 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Angiotensinogen (AGT) is the precursor of one of the most important vasoactive hormone angiotensin II and this gene locus is associated with human essential hypertension.
|
17475670 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension.
|
16940224 |
2006 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition to the angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) gene variants, gene-gene interactions may be important causative factors in a complex disease such as young-onset essential hypertension.
|
12611423 |
2003 |