Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no interaction between age of onset of ESRF and either the angiotensinogen M235T allele or angiotensin 1 receptor A1166C polymorphism.
|
9291178 |
1997 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphisms at the AGT and ACE gene loci are important markers for predicting progression to chronic renal failure in Caucasian patients with IgA nephropathy.
|
9259580 |
1997 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II, a potent vasoconstrictor, has a key role in renal injury and in the progression of chronic renal disease of diverse causes.
|
9428470 |
1998 |
Kidney Failure, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is of note that the presently reported patient did not exhibit any AGT catalytic activity and even so, he progressed towards end-stage renal disease only at 19 years old.
|
10737993 |
2000 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that ACE gene insertion/deletion and angiotensinogen M235T polymorphisms contribute to the increased risk for the development of CRF, but the magnitude of the effect within subsets of patients with specific etiologies of CRF must be evaluated further.
|
10916074 |
2000 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphism of the genes associated with angiotensin, including angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and the type 1 (AT1) and type 2 (AT2) angiotensin II receptors, has been implicated in the pathophysiology of hypertension, ischemic heart disease, and progression of chronic renal disease.
|
11544438 |
2001 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The AGT-TT genotype was associated with a faster progression to ESRD in patients with glomerulonephritis (P < 0.05).
|
11422735 |
2001 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the A1166C polymorphism at the angiotensin II type 1 (AT1R) locus in patients with end-stage renal disease (ESRD).
|
12187084 |
2002 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The alpha-adducin (ADD) gene, alone or in combination with the angiotensinogen (AGT) and the angiotensin-converting enzyme (ACE), is a candidate for abnormal blood pressure regulation and thus for increased susceptibility or faster progression to ESRD.
|
11918733 |
2002 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the effects of the AGT M235T and ATR A1166C polymorphisms on hypertension and age at the end stage renal disease (ESRD).
|
12950120 |
2003 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two hundred and forty-six end-stage renal disease (ESRD) patients on peritoneal dialysis and 183 control subjects, all of Chinese origin, were genotyped for the ACE insertion/deletion (I/D) and the AGT M235T gene polymorphisms.
|
12675870 |
2003 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Study of the polymorphism of angiotensinogen, anigiotensin-converting enzyme and angiotensin receptor in type II diabetes with end-stage renal disease in Taiwan.
|
12728975 |
2003 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms for association with susceptibility to primary vesicoureteral reflux (VUR) and disease progression in 74 Taiwanese children, including 16 with end-stage renal disease (ESRD), and 117 normal controls.
|
15045574 |
2004 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the distribution of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin receptor type 1 (ATR1) genetic polymorphisms in children affected by chronic renal failure due to renal hypodysplasia associated with posterior urethral valves or without urethral abnormalities.
|
16006956 |
2005 |
Kidney Failure, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Twelve-lead electrocardiograms (ECGs), serum electrolytes (sodium, potassium, and calcium), and ACE and angiotensin II levels were obtained 10 to 12 hours after a hemodialysis session in 43 patients with ESRD on chronic hemodialysis [mean age (+/-SD), 55 +/- 14 years].
|
16105049 |
2005 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the angiotensinogen -235T allele was found to be related with steroid resistance, renal dysfunction and progression of ESRD in nephrotic syndrome.
|
16525944 |
2005 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The attenuating effect of angiotensin II inhibitors on the progression of chronic renal disease is well recognized.
|
16830877 |
2006 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to evaluate the angiotensin-converting enzyme insertion/deletion (ACE-I/D), angiotensinogen (AGT) M235T, and angiotensin II receptor type 1 (ATR1) A1166C and type 2 (ATR2) C3123A gene polymorphisms as risk factors for progression to ESRD in patients with VUR.Methods.
|
19288324 |
2009 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, other endogenous substances with genotoxic properties, which are increased in ESRD, could be involved, such as the blood pressure regulating hormones angiotensin II and aldosterone or the inflammatory cytokine TNF-α.
|
22069557 |
2010 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the ACE, AGT, AT1R and CYP gene polymorphisms, only the DD genotype may predispose the individual to increased risk of progression to ESRD in the Chinese population.
|
21163122 |
2010 |
Kidney Failure, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Some patients with uremia due to ESRD exhibited significantly increased mAb 1G12 binding to blood ACE and increased ACE activity towards angiotensin I accompanied by reduced ACE inhibition by inhibitory mAbs and ACE inhibitors.
|
23166630 |
2012 |
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Discontinuing angiotensin II blockade resulted in recurrent glomerular destabilization, podocyte loss, and progression to ESKD.
|
21937979 |
2012 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there was no a markedly positive association between AGT M235T gene polymorphism and ESRD susceptibility in overall populations, Asians and Africans.
|
23065231 |
2013 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Examination of exome sequencing data in African American T2D-ESKD cases and non-diabetic non-nephropathy controls identified two low-frequency variants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with kidney function, as being associated with T2D-ESKD: rs9379084 (P = 0.00087, OR = 0.26; D1171N) and rs41302867 (P = 0.00078, OR = 0.21; splice site variant).
|
25027322 |
2014 |
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic studies highlighted two leading risk factors for preeclampsia: chronic renal disease and T235 homozygosity for the AGT gene.
|
25772015 |
2015 |