Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) have been recommended for patients with heart failure, their clinical and prognostic impact in the very acute phase of acute heart failure (AHF) is unclear, mainly because data on their safety and efficacy are lacking.
|
31218508 |
2019 |
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs.
|
21963897 |
2011 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We compared the effects of sudden stretch to SFR as well as to twitch and Ca2+ transient characteristics in rat myocardium with monocrotaline-induced heart failure with those in normal rat myocardium without and with inhibition of angiotensin II type-1 (AT1) receptors.
|
29593122 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, increased ACE/ACE2 ratios may induce angiotensin II over-activation and accelerate cardiac remodeling in patients with moderate to severe heart failure.
|
25869724 |
2015 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
As angiotensin II regulates both glomerular filtration rate (GFR) and erythropoiesis, RAS inhibition can further deteriorate renal function and lower hematocrit or cause anaemia in patients with heart failure.
|
31490340 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The standard pharmacotherapy for heart failure (HF), particularly HF with reduced ejection fraction (HFrEF), is primarily through the use of receptor antagonists, notably inhibition of the renin-angiotensin system by either angiotensin-converting enzyme inhibition or angiotensin II receptor blockade (ARB).
|
30484834 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The advanced heart failure and transplant programme formulated an institutional protocol for initiation of sacubitril/valsartan with defined criteria for switching from angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ARB).
|
31087629 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Conclusion Angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use is similar in preventing major cardiovascular outcomes regarding acute myocardial infarction, stroke and heart failure/hospitalisation.
|
28862020 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
To assess the clinical effectiveness of beta-blocker therapy in individuals with heart failure (HF) and chronic lung disease and of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) in individuals with HF and chronic kidney disease.
|
28873219 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (AngII) is implicated in many cardiovascular conditions, such as hypertension and heart failure.
|
28337024 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results strongly indicate that CSD suppresses AngII-induced pathological changes in mice, suggesting that CSD can be developed as a treatment for patients with hypertension and pressure overload-induced heart failure.
|
30576317 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The benefits of angiotensin II receptor blockers (ARBs) in patients with heart failure who are treated with standard pharmacotherapy, including an angiotensin-converting enzyme (ACE) inhibitor, were demonstrated in 2 large randomized trials.
|
18594050 |
2008 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study suggested that angiotensinogen gene variants M235T and T174M may provide prognostic information for long-term survival in heart failure patients.
|
17145981 |
2007 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-tomesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis.
|
30670148 |
2019 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, 4-month adult mice, on angiotensin II (Ang II) infusion, show rapid decline in cardiac systolic function, which leads to heart failure and death in 2 weeks.
|
31718444 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure.
|
29872396 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The number of atrial angiotensin II binding sites is reduced in end-stage human heart failure.
|
8872858 |
1996 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
1.The crucial role played by the renin-angiotensin-aldosterone system in the cardiovascular system and the immense therapeutic potential of angiotensin-converting enzyme inhibitors and, more recently, angiotensin II receptor blocking agents, in both heart failure and post-myocardial infarction is becoming increasingly evident.
|
9486084 |
1997 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Angiotensin-II (Ang-II) is associated with many conditions involving heart failure and pathologic hypertrophy.
|
23337087 |
2013 |
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure.
|
1330361 |
1992 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin insensitivity and adipokine abnormalities (the hallmarks of type 2 diabetes mellitus) are characteristic features of heart failure; conversely, neurohormonal systems activated in heart failure (norepinephrine, angiotensin II, aldosterone, and neprilysin) impair insulin sensitivity and contribute to microvascular disease in diabetes mellitus.
|
29038209 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A systematic search of PubMed and EMBASE was performed to collect all available information on ADRs to angiotensin-converting enzyme inhibitors, β-blockers, angiotensin II receptor blockers, mineralocorticoid receptor antagonists, ivabradine, and digoxin in both women and men with HF.
|
30819382 |
2019 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We noted that myocardial and plasma FGF23 and FGF receptor 4 were increased in mice with heart failure as well as in cultured adult mouse cardiac fibroblasts (AMCFs) exposed to angiotensin II, phenylephrine, soluble fractalkine.
|
27579618 |
2016 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interaction between interleukin‑6 and angiotensin II receptor 1 in the hypothalamic paraventricular nucleus contributes to progression of heart failure.
|
28440487 |
2017 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall, there was a significant association between angiotensinogen (AGT) gene M235T polymorphism and risk of heart failure in the subgroup analysis under the allelic contrast (T vs M: OR = 1.48, 95% CI: 1.04-2.11) and the dominant model (TT+MT vs MM: OR=1.67, 95% CI: 1.13-2.46) in the Caucasian population.
|
23154270 |
2014 |