Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice deficient both in ApoE and in kinin B1 receptor (ApoE(-/-)-B(1)(-/-)) were generated and analyzed for their susceptibility to atherosclerosis and aneurysm development under cholesterol rich-diet (western diet) and angiotensin II infusion.
|
19618151 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
(2) In an accelerated atherosclerosis model, with angiotensin II-induced aortic lesions and aneurysms, A-002 (30 mg/kg twice a day) reduced aortic atherosclerosis by approximately 40% (P < 0.05) and attenuated aneurysm formation (P = 0.0096).
|
19129734 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II has been shown to be proinflammatory and to promote atherosclerosis.
|
19762680 |
2009 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the discrepancy between HGF and VEGF, we compared the effects of HGF and VEGF on endothelial progenitor cells under angiotensin II stimulation, which is a well-known risk factor for atherosclerosis.
|
19047582 |
2009 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Angiotensin II and its type 1 receptor (AT1R) are both expressed in the adipose tissue and involved in the genesis of atherosclerosis as well as hypertension.
|
19696781 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis.
|
20500895 |
2010 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The atherosclerosis-enhancing effects of angiotensin II are complex and incompletely understood.
|
20504763 |
2010 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
During active disease, patients with granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) have accelerated atherosclerosis and ANGII inhibitors are recommended to these patients to reduce atherosclerosis.
|
21936613 |
2011 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
|
20945963 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis.
|
21451528 |
2011 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To further elucidate the role of COUP-TFII, we performed DNA microarrays in VEC transfected with the siRNA of COUP-TFII and subsequently stimulated with angiotensin II (AngII) and compared the expression profiles of 112 genes involved in various atherosclerosis-related pathways.
|
21069739 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that Th17 response may play an important role in angiotensin II-induced atherosclerosis.
|
21292406 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (Ang II) stimulates vascular smooth muscle cell (VSMC) hypertrophy as a critical event in the development of vascular diseases such as atherosclerosis.
|
21118843 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, endothelial-specific Nox2 overexpression did not alter native or angiotensin II-driven atherosclerosis in either the aortic root or the descending aorta.
|
22287576 |
2012 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to determine the effect of sRAGE in inhibiting AngII-induced atherosclerosis in apolipoprotein E knockout mice (Apo E KO).
|
23936343 |
2013 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population.
|
23497386 |
2013 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Additionally, lncRNAs have been associated with angiotensin II actions and with vascular diseases, including coronary heart disease and atherosclerosis. miRNAs, well studied in various vascular diseases, have also been recently shown to be differentially expressed in the biofluids of patients with vascular disease and mediate cell-cell communication.
|
24614861 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, in a model of enhanced vascular inflammation using angiotensin II, P2Y(6) deficiency enhanced formation of aneurysms and exhibited a trend towards increased atherosclerosis in the aorta of LDLR knockout mice.
|
25360548 |
2014 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF).
|
24942509 |
2014 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia in HCASMCs increases leptin expression through the induction of AngII, ROS, and the JNK pathway to enhance atherosclerosis in HCASMCs.
|
25573199 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have reported important roles of endothelin-1 (ET-1) and angiotensin II (Ang II) in the pathogenesis of atherosclerosis.
|
24877885 |
2015 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two of the 9 SNPs, rs2106261 (16q22) and rs6666258 (1q21), revealed interaction relationships that neared statistical significance (with point estimates in the same direction for angiotensin-converting enzyme inhibitor only and angiotensin II receptor blocker only analyses), but neither association could be replicated among 8,604 participants in Atherosclerosis Risk in Communities.
|
27179719 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II is well-recognised to be a key mediator in driving the pathological events of diabetes-associated atherosclerosis via signalling through its angiotensin II type 1 receptor (AT1R) subtype.
|
27168137 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, administration of rAngpt2 attenuated angiotensin II-induced aortic aneurysm and atherosclerosis in ApoE<sup>-/-</sup> mice associated with reduced aortic inflammation and angiogenesis.
|
27767064 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis.
|
26771341 |
2016 |