LPAR1, lysophosphatidic acid receptor 1, 1902

N. diseases: 145; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 AlteredExpression group LHGDN Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia. 19025891 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker group LHGDN Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. 17531530 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker group CTD_human Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells. 16809448 2006
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.300 Biomarker disease PSYGENET Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia. 16018581 2005
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2005
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker disease CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2005
CUI: C0003126
Disease: Anosmia
Anosmia 		0.300 Biomarker phenotype CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C0018273
Disease: Growth Disorders
Growth Disorders 		0.300 Biomarker group CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C0376634
Disease: Craniofacial Abnormalities
Craniofacial Abnormalities 		0.300 Biomarker group CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C0553757
Disease: Olfaction Disorders
Olfaction Disorders 		0.300 Biomarker group CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C1510410
Disease: Sense of smell altered
Sense of smell altered 		0.300 Biomarker phenotype CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C2718076
Disease: Fetal Mummification
Fetal Mummification 		0.300 Biomarker phenotype CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C3888024
Disease: Cacosmia
Cacosmia 		0.300 Biomarker disease CTD_human Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. 11087877 2000
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.240 Biomarker disease BEFREE Taken together, the data here demonstrated EDG2 was a potential predictor for HCC patients receiving liver resection and accelerated HCC progression via regulating EMT driven by PI3K/AKT/mTOR signaling. 29029500 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.240 Biomarker disease BEFREE We sought to determine the expression and function of endothelial differentiation gene (EDG) LPARs (LPAR1-3) in human HCC and complimentary in vitro models. 26701886 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.240 Biomarker disease BEFREE We report HCC-associated changes in LPAR1, 3, and 6 mRNA and protein expression, with significantly increased LPAR6 in HCC versus NL and NTL. 23182454 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.240 Biomarker disease BEFREE We thus demonstrate a mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades, providing novel biomarkers and potential therapeutic targets for HCC. 21102517 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.240 Biomarker disease RGD These results demonstrated that mutations in LPA1 gene occur in rat HCCs induced by DEN and the CDAA diet, suggesting that LPA1 mutations may be essentially involved in rat liver carcinogenesis. 19000703 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.210 Biomarker group BEFREE Hepatoma cells were treated with LPA in the absence or presence of LPAR1-3 (Ki16425) or pan-LPAR (α-bromomethylene phosphonate) antagonists and proliferation and motility were measured. 23182454 2013
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.210 Biomarker group RGD Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. 19000703 2009
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 Biomarker disease RGD Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. 19000703 2009
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.200 Biomarker disease RGD Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. 19000703 2009