Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study we investigated the ratio of circulating nitric oxide to endothelin-1 in patients with both SSc and PAH, and determined whether polymorphisms in NOS2 (the nitric oxide synthase 2 gene) are associated with susceptibility to PAH.
|
16813666 |
2006 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of endothelin-1 and endothelin-1 receptor A gene polymorphisms in patients with pulmonary arterial hypertension.
|
21773759 |
2012 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
The endothelin-1 (ET-1) pathway mediates vasoconstriction and is an established target of pulmonary arterial hypertension (PAH) therapy.
|
21838752 |
2012 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reflecting increased smooth muscle constriction in cells from PAH subject, Ca(2+) influx in response to endothelin-1 (ET-1) increased in all the PAH PASMC populations relative to the normal donor control cells.
|
22688668 |
2013 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 is a potent endogenous vasoconstrictor, which is considered to be central to many of the events that lead to PAH, and is an important therapeutic target in the treatment of the condition.
|
22960172 |
2012 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, important molecular pathways that are central to the pathogenesis of pulmonary arterial hypertension are reviewed, including nitric oxide, prostacyclin, endothelin-1, reactive oxygen species, and endothelial and smooth muscle proliferation.
|
24951762 |
2014 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In PAECs isolated from patients with pulmonary arterial hypertension, microRNA (miR)-98 expression was reduced, and ET-1 protein levels and proliferation were increased.
|
26098770 |
2016 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of PASMCs with the PAH mediators platelet-derived growth factor (PDGF), serotonin, H2O2, endothelin-1, and IL-6 caused significant increases in calpain activity, cell proliferation, and collagen-I protein level without changes in protein levels of calpain-1 and -2.
|
26248159 |
2016 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.
|
26252367 |
2015 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modafinil improved PAH by vasorelaxation and a decrease in medial thickening via ET-1, ERA, and KCa3.1 down regulation.
|
26959484 |
2016 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of exercise training on oxidative stress, metabolism, and markers of nitric oxide (NO) and endothelin-1 (ET-1) was analyzed in the lung tissue of rats with PAH induced by monocrotaline (MCT).Twenty-four Wistar rats were divided into four groups (5-7 animals): sedentary control (SC), sedentary MCT (SM), trained control (TC), and trained MCT (TM).
|
28181133 |
2017 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the prototypes MIL-89 and MIL-89 PEG with core capacity suitable to accommodate PAH drugs are relatively non-toxic and may have the added advantage of being anti-inflammatory and reducing the release of endothelin-1.
|
28447910 |
2019 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
The management of PAH has also become more complex, and numerous drugs are now approved that target the endothelin 1, nitric oxide, and prostacyclin pathways.
|
28593996 |
2017 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some biomarkers play important roles in the endothelial dysfunction of patients with pulmonary arterial hypertension (PAH), including nitric oxide (NO), endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA), galectin-3 (Gal-3), B-type natriuretic peptide (BNP), and uric acid (UA).
|
28608969 |
2017 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of control PASMC and PAEC to ET-1 fully mimicked the PAH cells phenotype, thus confirming that ET-1 is implicated in both metabolism and angiogenesis abnormalities in PAH.
|
29064353 |
2019 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unraveling endothelin-1 induced hypercontractility of human pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension.
|
29649319 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension.
|
29710468 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the increased protein expression of endothelin-1 (ET-1) and ET<sub>A</sub> receptor (ET<sub>A</sub>R), superoxide overproduction, and activation of Akt/ERK1/2/GSK3[Formula: see text]/[Formula: see text]-catenin pathway that occurred in the lungs of PAH rats were markedly reversed by BE treatment.
|
29737212 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
During the last thirty years since the discovery of endothelin-1, the therapeutic strategy that has evolved in the clinic, mainly in the treatment of pulmonary arterial hypertension, is to block the action of the peptide either at the ET(A) subtype or both receptors using orally active small molecule antagonists.
|
29947527 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pulmonary vascular remodeling in pulmonary arterial hypertension involves perturbations in the nitric oxide (NO) and endothelin-1 (ET-1) pathways.
|
30260284 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated that treatment with magnolol reduces the development of PAH induced by pneumonectomy and monocrotaline in rats, and suppressing Ang II and ET-1-mediated processes may contribute to its protective effects.
|
30466619 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dual antagonist to both endothelin-1 type A and B receptors, Macitentan, has been approved for clinical management of pulmonary arterial hypertension while little is known about the secondary effect of the drug on spine.
|
30911541 |
2019 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study sought to find a vaccine against endothelin-1 (ET-1) receptor type A (ETAR) for treating PAH.
|
31118151 |
2019 |
Idiopathic pulmonary arterial hypertension
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The regulation of ET-1 by iron was also demonstrated in healthy humans exposed to hypoxia and in PASMCs from PAH patients with mutations in bone morphogenetic protein receptor type II.
|
31152133 |
2019 |