EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Disease: Glioblastoma Multiforme ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE We further compared EGF +61 G/A polymorphism in patients with glioblastoma and Grade I-III glioma accordingly, the stronger association between the EGF +61 G/A polymorphism and the malignancy of glioma was found. 24740103 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Using 288 single cells, we constructed high-resolution phylogenies of EGF-driven and PDGF-driven GBMs, modeling transcriptional kinetics during tumor evolution. 27888226 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Kinase-deficient erbB proteins reduced epidermal growth factor (EGF)-induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained EGF-induced ERK MAPK activities in human glioblastoma cells, although basal ERK MAPK activities were unaffected. 10541432 1999
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE In addition, ectopic expression of α-catenin or depletion of β-catenin suppresses EGF-promoted glioblastoma cell migration, invasion, and proliferation. 20872274 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. 21896743 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Retroviral vectors made with the fusion protein were able to bind peptide antigen and EGFRvIII expressed on the surface of human glioblastoma cells. 10725459 2000
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Furthermore, astrocytoma cells expressing a constitutively phosphorylated and truncated EGF-R common in GBMs (EGFRvIII or p140(EGF-R)) demonstrate further elevations in Ras activation, resulting in a further increase in VEGF secretion. 10077162 1999
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Here, we found that expression of EphA3 is up-regulated in response to epidermal growth factor (EGF) stimulation and promotes formation of cell aggregates in suspension culture of glioblastoma cells. 30528229 2019
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. 23857604 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE We have observed levels of phosphorylation of STAT5 at position Y699 in cells expressing ΔEGFR that are similar or higher than in cells that overexpress EGFR and are acutely stimulated with EGF, prompting us to investigate the role of STAT5 activation in glioblastoma. 22729867 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE We investigated the genetic variants of EGFR, ERBB2, VEGFR and their ligands, EGF and VEGF on glioma and glioblastoma risk. 20446891 2010
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE The glioblastoma displayed EGF receptor amplification, and interestingly, it also displayed MYCN amplification; both tumors showed low level PTEN deletion. 22151431 2012
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. 24012640 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Seven GBM specimens showed specific binding for 125I-EGF, but it was less homogeneous when compared with IL13R or TfR. 10427128 1999
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE EGFRvIII is a truncated extracellular mutant of the EGF receptor (EGFR) found in about a third of GBMs. 23877363 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE These data indicate that overexpression of the EGF receptor and mutations of the p53 tumor suppressor gene are mutually exclusive events defining two different genetic pathways in the evolution of glioblastoma as the common phenotypic endpoint. 8864278 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells. 20565806 2010
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Our data from immunohistochemistry indicate that ERBB2 expression in GBM is closely correlated with EGF receptor levels and is therefore not useful as an independent prognostic parameter. 7760096 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Two transplantable cell lines of human glioblastoma multiforme GL-3 and GL-5 carried an amplification and overexpression of structurally altered epidermal growth factor (EGF) receptor gene: the 140 kilodalton EGF receptors in these cases exhibited a constitutively expressed tyrosine kinase activity without the ligand. 2168866 1990
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells. 3380099 1988
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE Activated EGFR signaling in these cells induced behaviors characteristic of GBM TSCs, including enhanced proliferation, survival and migration, even in the absence of EGF ligand. wtEGFR activation was also found to block neuronal differentiation and was associated with a dramatic increase in chemotaxis in the presence of EGF. 19855928 2010
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 Biomarker disease BEFREE A bispecific ligand-directed toxin (BLT), called EGFATFKDEL, consisting of human epidermal growth factor, a fragment of urokinase, and truncated pseudomonas exotoxin (PE38) was assembled in order to target human glioblastoma. 20830604 2011
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 AlteredExpression disease BEFREE Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 11515790 2001
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE The EGF receptor (EGFR) is amplified and mutated in glioblastoma, in which its common mutation (ΔEGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect. 24436148 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.400 GeneticVariation disease BEFREE EGF-R over-expression was identified in 4 (40%), which is consistent with previous reported studies for GBM in general. 8847560 1996