Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.
|
21896743 |
2011 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the genetic variants of EGFR, ERBB2, VEGFR and their ligands, EGF and VEGF on glioma and glioblastoma risk.
|
20446891 |
2010 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells.
|
20565806 |
2010 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, EGF-induced glioblastoma migration requires both ERK1/2 and PI3K activity.
|
20392929 |
2010 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors.
|
20199106 |
2010 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found 7 SNPs in haplotype 4 in EGF that were associated with prognosis in glioblastoma patients.
|
20197289 |
2010 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma.
|
17175377 |
2007 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association was observed between the EGF+61 polymorphism and glioblastoma or oligodendroglioma patients' overall survival.
|
17473192 |
2007 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma.
|
16885506 |
2006 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma.
|
15700833 |
2004 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.
|
12532415 |
2003 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The atypical protein kinase C inhibitor induced rapid apoptosis in glioblastoma cells expressing EGFRvIII and killed these cells with an IC50 of 16 microM.
|
12014630 |
2002 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells.
|
11515790 |
2001 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Retroviral vectors made with the fusion protein were able to bind peptide antigen and EGFRvIII expressed on the surface of human glioblastoma cells.
|
10725459 |
2000 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report the development and selection for a rearranged amplified EGF receptor, which lacks cytoplasmic amino acid sequences in a human glioblastoma xenograft.
|
10411339 |
1999 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor.
|
10576656 |
1999 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kinase-deficient erbB proteins reduced epidermal growth factor (EGF)-induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained EGF-induced ERK MAPK activities in human glioblastoma cells, although basal ERK MAPK activities were unaffected.
|
10541432 |
1999 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that overexpression of the EGF receptor and mutations of the p53 tumor suppressor gene are mutually exclusive events defining two different genetic pathways in the evolution of glioblastoma as the common phenotypic endpoint.
|
8864278 |
1996 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.
|
1693434 |
1990 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have compared the T-CAR1 cells with the human glioblastoma cell line T-MG1, which has 135,000 EGF-receptors and is growth stimulated by EGF.
|
1701094 |
1990 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells.
|
3380099 |
1988 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The gene encoding the receptor for epidermal growth factor was amplified two- to fivefold in the human glioblastoma cell line SF268.
|
3263568 |
1988 |