EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE A bispecific ligand-directed toxin (BLT), called EGFATFKDEL, consisting of human epidermal growth factor, a fragment of urokinase, and truncated pseudomonas exotoxin (PE38) was assembled in order to target human glioblastoma. 20830604 2011
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE We investigated the genetic variants of EGFR, ERBB2, VEGFR and their ligands, EGF and VEGF on glioma and glioblastoma risk. 20446891 2010
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE In contrast, EGF-induced glioblastoma migration requires both ERK1/2 and PI3K activity. 20392929 2010
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells. 20565806 2010
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE We found 7 SNPs in haplotype 4 in EGF that were associated with prognosis in glioblastoma patients. 20197289 2010
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors. 20199106 2010
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE No significant association was observed between the EGF+61 polymorphism and glioblastoma or oligodendroglioma patients' overall survival. 17473192 2007
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma. 17175377 2007
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma. 16885506 2006
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. 15700833 2004
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells. 12532415 2003
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE The atypical protein kinase C inhibitor induced rapid apoptosis in glioblastoma cells expressing EGFRvIII and killed these cells with an IC50 of 16 microM. 12014630 2002
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 11515790 2001
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Retroviral vectors made with the fusion protein were able to bind peptide antigen and EGFRvIII expressed on the surface of human glioblastoma cells. 10725459 2000
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Here we report the development and selection for a rearranged amplified EGF receptor, which lacks cytoplasmic amino acid sequences in a human glioblastoma xenograft. 10411339 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Kinase-deficient erbB proteins reduced epidermal growth factor (EGF)-induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained EGF-induced ERK MAPK activities in human glioblastoma cells, although basal ERK MAPK activities were unaffected. 10541432 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor. 10576656 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE These data indicate that overexpression of the EGF receptor and mutations of the p53 tumor suppressor gene are mutually exclusive events defining two different genetic pathways in the evolution of glioblastoma as the common phenotypic endpoint. 8864278 1996
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE We have compared the T-CAR1 cells with the human glioblastoma cell line T-MG1, which has 135,000 EGF-receptors and is growth stimulated by EGF. 1701094 1990
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 GeneticVariation disease BEFREE Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. 1693434 1990
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE The gene encoding the receptor for epidermal growth factor was amplified two- to fivefold in the human glioblastoma cell line SF268. 3263568 1988
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells. 3380099 1988