Malignant Neoplasms
|
0.400 |
CausalMutation
|
group |
CGI |
|
|
|
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Particularly salient are the following: (1) gene amplification is related to increasing grade of human glioma malignancy and occurs in approximately 40% of the most common and most malignant variety of glioma, glioblastoma multiforme (GBM), (2) by far the most commonly amplified gene in glioblastomas is the epidermal growth factor receptor (EGFR) gene, which is amplified in about one third of GBMs, (3) a small percentage of GBMs amplify N-myc or the novel sequence gli, (4) the EGFR gene is rearranged in at least half of gliomas in which it is amplified, and (5) EGFR gene rearrangement results in external domain deletions that yield truncated EGF receptors.
|
1374522 |
1992 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The occurrence of amplification and rearrangements at the EGFR gene locus is associated with malignancy in neuroepithelial tumours.
|
1447576 |
1992 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
To elucidate the possible roles of proto-oncogenes and growth factors in estrogen-regulated cell proliferation of human breast and gynecologic cancers, we have determined the gene expressions of c-myc, transforming growth factor-alpha and beta 1 (TGF-alpha, beta 1) and epidermal growth factor receptor (EGFR) in a number of these cancer cell lines by using an intron-Differential (ID) RNA/PCR method, which differentially identifies the amplified cDNA from PCR products of genomic DNA contaminants.
|
1696473 |
1990 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
EGFR gene amplification was detected in 16 of the 32 malignancy grade IV gliomas (glioblastoma) studied (50%), but only in 1 of 30 gliomas of lesser malignancy grade (I-III).
|
2009534 |
1991 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
TGFa mRNA was detected in a similar proportion of cancers as in neoplastic breast tissues but the TGFa receptor EGFR mRNA was detected in only 55% of breast cancers but in all non-neoplastic breast tissue tested.
|
2285595 |
1990 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased expression of epidermal growth factor receptor linked with abnormalities of chromosome 7 has been described in a number of malignancies, but not in premalignant lesions.
|
2390926 |
1990 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings suggest that increased ERBB3 expression, as in the case of epidermal growth factor receptor and ERBB2, may play a role in some human malignancies.
|
2687875 |
1989 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The epidermal growth factor receptor (EGFR) gene is frequently amplified and/or overexpressed in human malignancies.
|
3500791 |
1987 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Particularly loss of heterozygosity of chromosome 10 and eventually amplification of the EGFR indicate a high grade of malignancy.
|
7624652 |
1994 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The close relationship between aneuploidy, EGF-R positive expression, node involvement, and tumor invasion suggests that these parameters may be indicators of high malignancy.
|
7723282 |
1995 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The induction of EGFR and A20 by LMP1 may be an important component of EBV infection in epithelial cells and could contribute to the development of epithelial malignancies such as NPC.
|
7769701 |
1995 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Many studies have reported the increased expression of epidermal growth factor receptor (EGFR) in various human malignancies and its association with the biologic behavior of the tumors.
|
8039107 |
1994 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we used retroviral transfer of such a mutant receptor (de 2-7 EGFR) into glioblastoma cells expressing normal endogenous receptors to test whether the mutant receptor was able to augment their growth and malignancy.
|
8052651 |
1994 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The epidermal growth factor receptor (EGF-R) has been identified in these malignant neoplasms by immunohistochemical techniques.
|
8098266 |
1993 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, mutations within the EGFR that are unique to malignancies may provide specific targets for immunotherapeutic intervention.
|
8391918 |
1993 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Specimens from 22 patients with tumors of borderline malignancy (11 serous and 11 mucinous tumors), 12 patients with benign tumors, and 16 patients with invasive ovarian carcinomas were evaluated for expression of epidermal growth factor receptor (EGFR), HER-2/neu, PTP1B, and p53 by immunohistochemical techniques.
|
8640675 |
1996 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The tyrosine kinase receptor family, including the epidermal growth factor receptor (EGF-R), c-erbB2 and, more recently, the c-erbB3, has been recognized as being of particular importance in many human malignancies.
|
8669836 |
1996 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The epidermal growth factor receptor (EGFr) family has been increasingly recognized as an important component in the control of normal cell proliferation and the pathogenesis of cancer.
|
8678944 |
1996 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
EGFR staining was negligible in normal mucosa from control patients without cancer and relatively increased in SCCHN tissues.
|
8826952 |
1996 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deregulation of signaling by the epidermal growth factor receptor (EGFR) is common in human malignancy progression.
|
9006938 |
1997 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The epidermal growth factor receptor (EGFR) system has been implicated in the etiology of numerous cancers, including that of ovarian cancer.
|
9103388 |
1997 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epidermal growth factor receptor (EGFR) is overexpressed in various malignancies including carcinoma of the breast, lung, esophagus, cervix, and stomach.
|
9149012 |
1997 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This abnormality of EGFR gene expression is closely related to the malignancy of glioma.
|
9216693 |
1997 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A human cancer cell line was found to be heterogeneous for expression of the epidermal growth factor receptor (EGFR).
|
9458333 |
1998 |