|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
|
22753918 |
2012 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient.
|
25053390 |
2014 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung.
|
21684624 |
2011 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ten of 215 pure SQCCs (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR.
|
24158231 |
2014 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung.
|
17186532 |
2007 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer.
|
20635059 |
2010 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Detection and monitoring of driver mutations by next-generation sequencing in squamous cell lung cancer patient and possible predictive biomarker of third generation EGFR-tyrosine kinase inhibitors.
|
29143497 |
2018 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma.
|
31660987 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice.
|
17533397 |
2007 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations.
|
26216950 |
2015 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
EGFR mutation is associatedwith short PFS and the brain is the most common site of distant metastasis in patients with stage III non- squamous cell lung cancer treated with CCRT.
|
29914238 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung cancer subtype (P<0.01).
|
31518089 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Significant differences in NIC, K values, and calcium content were observed between the EGFR-positive and EGFR-negative groups among patients with SC.
|
29752156 |
2018 |
|
Squamous cell carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of human squamous cell lung carcinoma specimens.
|
24464917 |
2014 |
|
Squamous cell carcinoma of lung
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma.
|
20942962 |
2010 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To analyze the distribution of epidermal growth factor receptor (<i>EGFR</i>) mutations; characterize the clinical and imageological features of lung squamous cell carcinoma (LSCC) in a large population of patients; and assess correlations between clinical and imageological characteristics and clinical outcomes of LSCC patients harboring <i>EGFR</i> mutations.
|
31695493 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients.
|
22420950 |
2012 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An <i>EGFR</i> Sensitizing Mutation.
|
31802898 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
More macrophages were found in lung squamous cell carcinoma (LUSC) patients, patients with wild-type EGFR, and smokers than in patients with lung adenocarcinoma (LUAD), patients with EGFR mutations, and non-smokers.
|
31308749 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found EGFR-mutant LUAD showed significantly higher ITHi than KRAS-mutant LUAD/wild-type LUAD (P = 0.03) and numerically higher ITH than LUSC.
|
30626401 |
2019 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the feasibility of applying this method to mediastinal lymph node metastases in an epidermal growth factor receptor (EGFR)-positive squamous cell carcinoma of the lung.
|
29856819 |
2018 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Epidermal Growth Factor Receptor Inhibition in the Management of Squamous Cell Carcinoma of the Lung.
|
26768483 |
2016 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Efficacy of postoperative radiotherapy in patients with pathological stage N2 epidermal growth factor receptor wild type adenocarcinoma and squamous cell carcinoma lung cancer.
|
27835914 |
2017 |
|
Squamous cell carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The EGFR-TKIs had a modest response for EGFR mutated lung squamous cell carcinoma patients and might be a selective option for those patients.
|
28881841 |
2017 |
|
Squamous cell carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Survival analysis found that TP53 and EGFR showed a significant correlation (log rank P = 3e-07 and 0.023) with lung adenocarcinoma and lung squamous cell carcinoma, according to KM analysis.
|
31544704 |
2019 |