EGFR, epidermal growth factor receptor, 1956

N. diseases: 1394; N. variants: 183
Disease: Malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutations were found in additional lung cancer samples from U.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. 15118125 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. 16140919 2005
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutation was significantly correlated with gender, smoking status, pathological subtypes, and differentiation of lung cancers. 16199108 2005
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutations occur in highly selected subpopulations of lung cancer patients: adenocarcinoma histology, never-smoker status, East Asian ethnicity and female gender. 16231326 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor (EGFR) gene mutations are frequently detected in lung cancer, especially in adenocarcinoma, in females, and non-smoking patients. 16503085 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib. 16510849 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 Biomarker disease BEFREE Epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer: impact of primary or secondary mutations. 16764754 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor mutation testing in the care of lung cancer patients. 16857818 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutations were detected by both DHPLC procedure and direct sequencing using lung cancer tissue samples obtained from 97 patients (81 surgical specimens and 16 pleural effusions of non-resectable lung cancer patients). 16947044 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation. 17001163 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. 17052295 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor mutations in lung cancer. 17318210 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. 17332364 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy. 17353898 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 AlteredExpression disease BEFREE Epidermal growth factor receptor (EGFR) is a transmembrane receptor overexpressed in high percentage lung cancers, and contributes to tumor growth. 17643093 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR insertion mutations at exon 20 were found from 7 of 322 (2.17%) lung cancer patients. 17686547 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 Biomarker disease BEFREE EGFR tyrosine kinase inhibitors in lung cancer: an evolving story. 17716025 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 Biomarker disease BEFREE EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. 18304967 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. 18381415 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE Epidermal growth factor receptor (EGFR) mutations in lung cancer enhance tyrosine kinase activity and increase sensitivity to the EGFR tyrosine kinase inhibitor, gefitinib. 18422739 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutation at C-terminal in lung cancers seemed to be extremely rare, however, this D1012H mutation might be a role in EGFR function. 18478265 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR-tyrosine kinase polymorphism might be associated with clinicopathological background of lung cancers. 18541260 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 Biomarker disease BEFREE EGFR assays in lung cancer. 18580100 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. 18726117 2009
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.600 GeneticVariation disease BEFREE EGFR mutation status was not correlated with the FGFR4 genotype of lung cancers. 18949411 2008