|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
GAK appears to be essential for cell death because co-administration of gefitinib and luteolin to EGFR-deficient U2OS osteosarcoma cells also had a greater effect on cell viability than administration of either compound alone.
|
24971999 |
2014 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that TGF-α/EGFR interaction elicits PI3K and Akt activation, which in turn activates NF-κB, resulting in the expression of ICAM-1 and contributing the migration of human osteosarcoma cells.
|
24685520 |
2014 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we reported significant lower level of miR-143 and significant levels of phosphorylated EGFR and MMP9 in the resected OS from the patients, compared to the adjacent normal tissue.
|
25227664 |
2014 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nutlin-3 induced the phosphorylation of EGFR, MAPK/ERK kinase (MEK)1/2 and extracellular signal-regulated kinase (ERK)1/2 in U2OS human osteosarcoma cells harboring wild-type p53.
|
23314357 |
2013 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Met interacts with EGFR and Ron in canine osteosarcoma.
|
22235915 |
2013 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species.
|
21236332 |
2011 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study describes further investigations into the role of ERs in mediating the effects induced by E(2) and SERMs on EGFR expression, and the relationship between the actions of ERs and EGFR in U2OS osteosarcoma cells stably expressing ERalpha or ERbeta.
|
19347870 |
2009 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Two out of three osteosarcoma cell lines showed increased EGFR levels as detected by real-time PCR.
|
19212684 |
2009 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas.
|
18464244 |
2008 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas.
|
18464244 |
2008 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EGFR expression was detected in the majority of osteosarcoma tumors surveyed (23 of 28; 82%).
|
18704985 |
2008 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
EGFR expression was detected in the majority of osteosarcoma tumors surveyed (23 of 28; 82%).
|
18704985 |
2008 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Six of 12 (50%) osteosarcoma cell lines revealed moderate to high expression levels of EGFR.
|
17509661 |
2007 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The new virus displayed a highly selective targeting profile, with reduced infection of EGFR-negative cells and efficient killing of EGFR-positive cancer cells including primary EGFR-positive osteosarcoma cells that are refractory to infection by conventional adenoviruses.
|
17184803 |
2007 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ninety-one of 111 (81%) of osteosarcomas revealed an expression of EGFR.
|
17505002 |
2007 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Six of 12 (50%) osteosarcoma cell lines revealed moderate to high expression levels of EGFR.
|
17509661 |
2007 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We conclude that the cell surface expression of Her-2 and EGFR and the nuclear localization of the activated p80 fragment of Her-4 suggest that all three may be contributing to osteosarcoma pathogenesis.
|
15026342 |
2004 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that the cell surface expression of Her-2 and EGFR and the nuclear localization of the activated p80 fragment of Her-4 suggest that all three may be contributing to osteosarcoma pathogenesis.
|
15026342 |
2004 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry on primary tumor samples and FACS analysis on primary short-term cultures and four OS cell lines showed that EGFR was consistently expressed.
|
12221644 |
2003 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with transcriptional repression of the endogenous epidermal growth factor receptor.
|
9108440 |
1997 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Exogenously introduced wild-type and mutant p53 have recently been reported to enhance the human epidermal growth factor receptor (EGF-R) gene promoter activity in p53-deficient Saos2 osteosarcoma cells.
|
9285564 |
1997 |