EGFR, epidermal growth factor receptor, 1956

N. diseases: 1394; N. variants: 183
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 AlteredExpression disease BEFREE Twelve glioblastomas (40%) showed amplification of the EGFR gene, and overexpression of EGFR was evident in each of these tumors as indicated by the immunoperoxidase technique. 7815080 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE The other patient had a glioblastoma which contained amplified epidermal growth factor receptor (EGFR) genes, and amplified EGFR gene sequences were present in her CSF. 7912724 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE In astrocytomas, for example, losses of genetic material on chromosomes 10 and 17 and amplification of the epidermal growth factor receptor gene seem important in pathogenesis, with the loss of chromosome 10 and the amplification of epidermal growth factor receptor being strongly associated with glioblastoma multiforme. 8008171 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE The oncogene MET was amplified in a glioblastoma which showed no EGFR gene amplification. 8017863 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE Western blot analysis with anti-phosphotyrosine antibody indicates that the mutant receptor is constitutively phosphorylated in CHO cells, and the same analysis applied to lysates of glioblastoma biopsies reveals the altered receptor is readily detectable as a phosphotyrosine protein in tumors for which there is evidence of corresponding EGFR gene and transcript alterations. 8036013 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE Here we used retroviral transfer of such a mutant receptor (de 2-7 EGFR) into glioblastoma cells expressing normal endogenous receptors to test whether the mutant receptor was able to augment their growth and malignancy. 8052651 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE To characterize some of the genetic events underlying the development of glioblastoma multiforme, the authors analyzed 65 astrocytic tumors (seven pilocytic astrocytomas, eight astrocytomas, 16 anaplastic astrocytomas, and 34 glioblastomas multiforme) for loss of heterozygosity for chromosome 17p, loss of heterozygosity for chromosomes 10p and 10q, amplification of the epidermal growth factor receptor (EGFR) gene, and amplification of the oncogenes N-myc, c-myc, and N-ras using Southern blot analysis. 8057151 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma. 8262681 1994
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE In addition, those glioblastomas with a loss of chromosome 17p occurred in patients significantly younger than those with glioblastomas characterized by EGFR gene amplification (p = 0.001). 8269081 1993
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE For example, one mutant form, the type III deletion mutant of the EGFR, that has been identified in glioblastomas contains a novel peptide sequence in its extracellular domain which is detectable by anti-peptide antisera. 8391918 1993
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 AlteredExpression disease BEFREE Expression of epidermal growth factor receptor in human glioblastoma multiforme. 8393321 1993
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 AlteredExpression disease BEFREE The first three have been reported in a few per cent of malignant gliomas, and EGFR in around 40% of glioblastomas. 8448375 1993
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE This finding contradicts the hypothesis that deletion of one entire chromosome 10 regularly precedes EGFR gene amplification in primary glioblastomas of patients aged over 50 years. 8568531 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE The most commonly amplified genes in glioblastomas are EGFR (in approximately 40%), CDK4, and SAS (in approximately 15%). 8586464 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE Immunostaining of glioblastomas revealed binding in the case with the type III EGFR mutation, the five other specimens without the mutation being negative despite overexpression of EGFR in some cases. 8645581 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE A positive EGFR immunoreaction was detected in seven (16%) of 44 WHO Grade II astrocytomas, five (26%) of 19 WHO Grade III astrocytomas, and 32 (52%) of 62 WHO Grade IV glioblastomas. 8814167 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE Only one out of 49 glioblastomas showed EGFR overexpression and a p53 mutation. 8864278 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. 8895767 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE Hydroxyurea accelerates the loss of epidermal growth factor receptor genes amplified as double-minute chromosomes in human glioblastoma multiforme. 8905754 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE EGFRvIII is a mutant epidermal growth factor receptor found in glioblastoma, and in carcinoma of the breast, ovary, and lung. 8962138 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE None of the primary low-grade and none of the recurrent high-grade tumors (7 anaplastic astrocytomas, 10 anaplastic oligodendrogliomas, 4 anaplastic oligoastrocytomas, and 5 glioblastomas) showed evidence of EGFR gene amplification. 8965097 1996
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 Biomarker disease BEFREE We have selectively targeted the EGFr in human glioblastoma cells with kinase-deficient mutants of the erbB family derived from the ectodomain of the Neu oncogene that are able to form heterodimers with EGFr and inhibit EGFr-dependent phenotypes. 9096379 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 AlteredExpression disease BEFREE Our results are at variance with similar studies in adult patients in which primary and secondary glioblastomas are characterized by EGFR overexpression and p53 mutations, respectively, suggesting that the evolution of pediatric glioblastomas follows different genetic pathways. 9210874 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. 9217972 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.700 GeneticVariation disease BEFREE PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. 9393744 1997