Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
SNP 2 (located in the first intron of ELAVL4) showed a strong significant association with AAO of PD (P = 0.006), and SNP 5 (a coding SNP in ELAVL4) showed a moderately significant association (P = 0.035).
|
15827745 |
2005 |
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.
|
17230446 |
2007 |
Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells.
|
16384890 |
2006 |
Central neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells.
|
16384890 |
2006 |
Childhood Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells.
|
16384890 |
2006 |
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report the identification of several HuD target transcripts linked to Alzheimer's disease (AD) pathogenesis.
|
24857657 |
2014 |
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.
|
31242416 |
2019 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in vitro, is recognized by sera from anti-ELAVL4 positive SCLC patients and is highly immunogenic in subcutaneously injected mice and in vitro stimulated human lymphocytes.
|
27725125 |
2016 |
Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We suggest that ELAVL4 can be involved in the pathogenesis of meningiomas in male patients.
|
22965691 |
2013 |
Spinal Muscular Atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expert commentary: The identification of genetic modifiers such as PLS3 and NCALD in humans or of SMA modulators such as Elavl4 (HuD), Copa, Uba1, Mapk10 (Jnk3), Nrxn2 and Tmem41b (Stasimon) in various SMA animal models improved our knowledge of impaired cellular pathways in SMA.
|
28635376 |
2017 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved.
|
27725125 |
2016 |
Disseminated neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used real-time quantitative reverse transcription-PCR (QPCR) of the tyrosine hydroxylase (TH), GD2 synthetase (GALGT), and embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) genes to detect disseminated neuroblastoma cells.
|
16384890 |
2006 |
Stage 4S neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used real-time quantitative reverse transcription-PCR (QPCR) of the tyrosine hydroxylase (TH), GD2 synthetase (GALGT), and embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) genes to detect disseminated neuroblastoma cells.
|
16384890 |
2006 |
Small cell carcinoma of lung
|
0.060 |
AlteredExpression
|
disease |
LHGDN |
Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer.
|
18607064 |
2008 |
Small cell carcinoma of lung
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons.
|
14512168 |
2003 |
Small cell carcinoma of lung
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer.
|
9288629 |
1997 |
Small cell carcinoma of lung
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These results show that the HuD gene is not mutated in lung cancer, including tumors from patients producing anti-HuD antibodies, but HuD expression is an independent marker or determinant of the neuroendocrine differentiation seen in SCLC.
|
8069866 |
1994 |
Malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer.
|
9288629 |
1997 |
Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells.
|
28739747 |
2017 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer.
|
9288629 |
1997 |
Central neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells.
|
28739747 |
2017 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer.
|
9288629 |
1997 |
Childhood Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells.
|
28739747 |
2017 |
Adult Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of ELAVL4 in male meningioma patients.
|
22965691 |
2013 |
Meningioma, benign, no ICD-O subtype
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of ELAVL4 in male meningioma patients.
|
22965691 |
2013 |