|
Achondroplasia
|
0.210 |
Biomarker
|
disease |
BEFREE |
Here we show that lack of functional Spred-2 protein in mice caused a dwarf phenotype, similar to achondroplasia, the most common form of human dwarfism.
|
15946934 |
2005 |
|
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we found that CML CD34+ cells expressed lower level of Spred2 compared with normal hematopoietic progenitor cells, and adenovirus mediated restoration of Spred2 promoted the erythroid differentiation of CML cells.
|
25688862 |
2015 |
|
Myeloid Leukemia, Chronic
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells.
|
20153728 |
2010 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, miR-487a mainly promotes metastasis via SPRED2 induced mitogen activated protein kinase signaling and promotes proliferation via PIK3R1 mediated AKT signaling.
|
27827315 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The present study demonstrates that the METTL3/miR-1246/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in CRC development.
|
31492150 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Most importantly, the knockdown of Spred2 markedly enhanced tumor growth in vivo.
|
21703232 |
2011 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These data suggest first evidence that SPRED2 is downregulated in prostate cancer and warrants further investigation as a potential tumour-suppressor gene.
|
23169297 |
2013 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggest that Spred2 could qualify as a potential therapeutic target in HCC.
|
21703232 |
2011 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Vice versa, SPRED2 deficiency impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias.
|
30771306 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Increased miR-210 and reduced SPRED2 levels were found in aorta of mice under high-fat diet and tumor tissues, which implied that miR-210 can be an underlying mechanism to explain oxLDL as a common risk factor for cardiovascular disease and gastrointestinal cancer.
|
26254226 |
2015 |
|
Dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that lack of functional Spred-2 protein in mice caused a dwarf phenotype, similar to achondroplasia, the most common form of human dwarfism.
|
15946934 |
2005 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated whether Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, plays a role in the development of high fat diet (HFD)-induced obesity, adipose tissue inflammation, metabolic abnormalities, and insulin resistance.
|
30723473 |
2019 |
|
Obsessive-Compulsive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that OCD-like behavior in mice is caused by deficiency of SPRED2, a protein expressed in various brain regions and a potent inhibitor of Ras/ERK-MAPK signaling.
|
28070119 |
2018 |
|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
Excessive self-grooming, reflecting OCD-like behavior in rodents, resulted in facial skin lesions in SPRED2 knockout (KO) mice.
|
28070119 |
2018 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
Spred2 knockout (KO) mice, fed with HFD, exhibited an augmented body weight gain, which was associated with enhanced adipocyte hypertrophy in mesenteric white adipose tissue (mWAT) and deteriorated dyslipidemia, compared with wild-type (WT) controls.
|
30723473 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In functional assays, SPRED2 overexpression reduced ERK phosphorylation and inhibited prostate cancer cell proliferation and migration in response to different growth factors and full-media stimulation (P<0.001).
|
23169297 |
2013 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Spred2 represents a potential therapeutic tool for the prevention of insulin resistance and resultant metabolic syndrome.
|
30723473 |
2019 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In functional assays, SPRED2 overexpression reduced ERK phosphorylation and inhibited prostate cancer cell proliferation and migration in response to different growth factors and full-media stimulation (P<0.001).
|
23169297 |
2013 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased miR-210 and reduced SPRED2 levels were found in aorta of mice under high-fat diet and tumor tissues, which implied that miR-210 can be an underlying mechanism to explain oxLDL as a common risk factor for cardiovascular disease and gastrointestinal cancer.
|
26254226 |
2015 |
|
Septic peritonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance.
|
28993690 |
2017 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The present study demonstrates that the METTL3/miR-1246/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in CRC development.
|
31492150 |
2019 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exacerbated adipose tissue inflammation in Spred2 KO mice led to aggravated insulin resistance and fatty liver disease.
|
30723473 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |