|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, FLCN, similarly to VHL, is necessary for the activity of LC3C-mediated autophagic program that we have previously characterized as contributing to the tumor suppressing activity of VHL.
|
23922894 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the truncated protein was still expressed both in cell culture and in tumor tissue, though it was strongly destabilized and its subcellular localization differed from wild-type FLCN.
|
28499369 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Most cancer-causing mutations lead to a carboxy-terminal truncation of folliculin, pointing to a functional importance of this domain in tumour suppression.
|
22977732 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutated RRAGC proteins demonstrated increased binding to RPTOR (raptor) and substantially decreased interactions with the product of the tumor suppressor gene FLCN (folliculin).
|
27267853 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the one hand, CDK4 phosphorylated the tumor suppressor folliculin (FLCN), regulating mTORC1 recruitment to the lysosomal surface in response to amino acids.
|
31395606 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study suggests that FLCN functions as a tumor suppressor by negatively regulating rRNA synthesis.
|
23077212 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our work highlights a mechanism explaining, at least in part, the tumour suppressor function of FLCN.
|
28656962 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.
|
23150719 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Second "hit" FLCN mutations in BHD kidney tumors and loss of tumorigenic potential of the FLCN-null UOK257 tumor cell line when FLCN is re-expressed underscore a tumor suppressor role for FLCN.
|
23108783 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Sequencing all exons from genomic DNA failed to disclose mutations of the folliculin gene in any of the tumors.
|
14961590 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Spontaneous pneumothoraces due to lung cyst rupture afflict patients with the rare disease Birt-Hogg-Dubé (BHD) syndrome, which is caused by mutations of the tumor suppressor gene folliculin (FLCN).
|
24726356 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Folliculin (FLCN) is a GAP for RagC/D, a regulator of mTOR.
|
30843872 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) activating protein (GAP) activity toward the GTPase RagC.
|
31672913 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The finding that mutant FLCN was expressed in the tumour might indicate residual functionality of mutant FLCN, a notion which will be explored in future studies.
|
23264078 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The function of the BHD product, called folliculin, is still unknown, although it is speculated to be a tumor suppressor gene.
|
17149965 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The precise functions of the FLCN gene product are still under investigation but RCC from BHD patients show loss of the wild-type allele consistent with a tumor suppressor gene function.
|
23416984 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present identification of two mutations not only further supports the important role of tumor suppressor FLCN in BHD and primary spontaneous pneumothorax, but also expands the spectrum of <i>FLCN</i> mutations and will provide insight into genetic diagnosis and counseling of families with BHD.
|
28785590 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The responsible gene FLCN is a tumor suppressor for kidney cancer, which plays an important role in energy homeostasis through the regulation of mitochondrial oxidative metabolism.
|
29767721 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data uncover important roles for FLCN in salivary gland; metabolic reprogramming under FLCN deficiency might increase nucleotide production which may feed FLCN-deficient salivary gland cells to trigger tumor initiation and progression, providing mechanistic insight into salivary gland tumorigenesis as well as a foundation for development of novel therapeutics for salivary gland tumors.
|
31806376 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that FLCN functions as a tumour suppressor that inhibits renal carcinogenesis.
|
23223565 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This is most likely related to haploinsufficiency of FLCN gene, located in the deleted region, and a known tumor suppressor gene.
|
27633572 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This sheds light on the pathogenesis of BHDS and the role of FLCN as a tumor suppressor gene.
|
31778855 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To examine the tumor suppressor function of FLCN, wild-type or mutant FLCN (H255R) was stably expressed in a FLCN-null renal tumor cell line, UOK257, derived from a BHD patient.
|
20573232 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Two animal models and studies of renal cancers support a tumor-suppressor function for folliculin.
|
16825879 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that, similarly to PTEN, FLCN may not always follow the classical Two Hits model of tumorigenesis and may hence belong to a class of non-canonical tumour suppressor genes.
|
23386036 |
2013 |