|
Autism Spectrum Disorders
|
0.590 |
Biomarker
|
disease |
MGD |
|
|
|
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Adenocarcinoma human alveolar basal epithelial A549 cells were transfected with negative control plasmids or those containing EN2, enabling its overexpression.
|
29963129 |
2018 |
|
Retinal defect
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Retinal defects in mice lacking the autism-associated gene Engrailed-2.
|
30980901 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer.
|
21364037 |
2011 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) has been identified as a candidate oncogene in breast cancer and prostate cancer.
|
24786097 |
2014 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) has been identified as a candidate oncogene in breast cancer and prostate cancer.
|
24786097 |
2014 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) has been identified as a candidate oncogene in breast cancer and prostate cancer.
|
24786097 |
2014 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) has been identified as a candidate oncogene in breast cancer and prostate cancer.
|
24786097 |
2014 |
|
Hyperactive behavior
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Engrailed-2 promoter hyper-methylation is associated with its downregulation in clear cell renal cell carcinoma.
|
29151918 |
2017 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription.
|
29894832 |
2018 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription.
|
29894832 |
2018 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription.
|
29894832 |
2018 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription.
|
29894832 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (EN2) protein, a potential biomarker for various cancers such as prostate cancer, bladder cancer, breast cancer and ovarian cancer, is known to be a strong binder to a specific DNA sequence (50-TAATTA-30) to regulate transcription.
|
29894832 |
2018 |
|
Social Communication Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Engrailed-2 (En2) is a transcription factor critical for neural development, and mice lacking En2 (En2<sup>-/-</sup>) display signs of impaired social interaction, cognitive processes (e.g., learning and memory, conditioned fear), and neurodevelopmental alterations.
|
29953887 |
2018 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A recent study has shown an association between urinary EN2 levels and cancer volume in radical prostatectomy specimens.
|
23937390 |
2014 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A recent study has shown an association between urinary EN2 levels and cancer volume in radical prostatectomy specimens.
|
23937390 |
2014 |
|
Autism Spectrum Disorders
|
0.590 |
Biomarker
|
disease |
BEFREE |
Accordingly, mice lacking the En2 homeodomain (En2<sup>hd/hd</sup>, referred to as En2<sup>-/-</sup>) show molecular, anatomical and behavioral "ASD-like" features.
|
29964155 |
2018 |
|
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the WNT2 gene and EN2 gene may act in concert to influence the language development in autism.
|
22522212 |
2012 |
|
Language Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Additionally, two other genes on 7q31-36, FOXP2 and the EN2 genes are also found to play a role in language impairment.
|
22522212 |
2012 |
|
Young onset Parkinson disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Altogether, our data suggest the possibility that variations of the engrailed-2 gene are implicated in the development of YOPD, although our results with respect to SNP rs1345514 should be verified in an independent sample.
|
19270442 |
2009 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa.
|
31500112 |
2019 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa.
|
31500112 |
2019 |
|
Autism Spectrum Disorders
|
0.590 |
Biomarker
|
disease |
BEFREE |
As such, En2<sup>-/-</sup> mice display the behavioral deficits and neural impairments characteristic of the core symptoms associated with autism spectrum disorder (ASD).
|
29953887 |
2018 |
|
Autism Spectrum Disorders
|
0.590 |
AlteredExpression
|
disease |
BEFREE |
Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.
|
15024396 |
2004 |