Malignant neoplasm of lung
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Malignant neoplasm of lung
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported that both homozygote carriers of the A-allele as well as homozygous carriers of a high-risk haplotype (which includes the AA genotype in ERCC1 G19007A) were at increased risk of basal cell carcinoma, breast cancer, and lung cancer among Caucasians.
|
16341770 |
2005 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no overall association between ERCC1 polymorphisms and lung cancer risk, with the adjusted odds ratios (AOR) of 1.26 [95% confidence interval (95% CI), 0.81-1.96] for the 8092C > A polymorphism (A/A versus C/C) and 0.93 (95% CI, 0.67-1.30) for the 19007T > C polymorphism (C/C versus T/T).
|
15734977 |
2005 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that ERCC1 Asn118Asn (G19007A) polymorphism may play a limited role for lung cancer in this Chinese population.
|
16364765 |
2006 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study indicated no association between mRNA expression of the DNA-repair genes ERCC1 and XPD and risk of subsequent development of lung cancer.
|
16054657 |
2006 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.
|
17314339 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study.
|
16690207 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that ERCC1 polymorphisms may contribute to the etiology of lung cancer.
|
17502833 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and ERCC5/XPG.
|
17299578 |
2007 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using immunohistochemistry in resected tumors, the International Adjuvant Lung Cancer Trial showed that high ERCC1 protein expression was associated with improved survival in patients who did not receive chemotherapy.
|
17534174 |
2007 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of excision repair cross-complementation group 1 (ERCC1) protein in 90 completely resected lung cancer samples from patients who received adjuvant or neo-adjuvant platinum-based chemotherapy.
|
18395930 |
2008 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using a panel of 20 lung cancer cell lines, including 15 NSCLC and 5 small cell lung cancers (SCLC), the mRNA expression levels for the RRM1, ERCC1 and ERCC2 genes were examined by quantitative real-time reverse transcription PCR.
|
18494946 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested whether genetic variants in the ERCC1 gene are associated with susceptibility to lung cancer and efficacy of platinum-chemotherapy in patients with small cell lung cancer (SCLC).
|
18451256 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer.
|
18289367 |
2008 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that ERCC-1 was involved in the resistance of cetuximab combined with DDP as overexpression of ERCC-1 prohibits the activation of EGFR pathway, which would facilitate the preselection of lung cancer patients for the treatment of cetuximab combined with DDP.
|
20009541 |
2009 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In order to comprehensively capture common genetic variation in the ERCC1 gene, Caucasian data from the International HapMap project was used to assess linkage disequilibrium and choose four tagSNPs (rs1319052, rs3212955, rs3212948, and rs735482) in the ERCC1 gene to genotype 452 lung cancer cases, 175 H&N cancer cases, and 790 healthy controls.
|
20863778 |
2011 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphism Asn118Asn in ERCC1, A67T in iASPP and Asn148Glu in APE1 may associated with early onset of lung cancer as well as some specific subtype of lung cancer.
|
20354815 |
2011 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Excision repair cross-complementation group 1 (ERCC1) status and lung cancer outcomes: a meta-analysis of published studies and recommendations.
|
22022380 |
2011 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant associations with lung cancer susceptibility were observed for global or individual haplotypes defined by five htSNPs of ERCC1.
|
21601580 |
2011 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis.
|
21933627 |
2011 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two tests in lung cancer (ERCC1 and EGFR) and 1 test in breast cancer (CEA/CA15-3/CA27.29) were identified as top research priorities.
|
22274803 |
2012 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The authors investigated whether p38 MAPK activity contributed to the viability of cisplatin in lung cancer cell lines from never or light smokers and to ERCC1 mRNA expression.
|
22415779 |
2012 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
|
22351191 |
2012 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A Chinese case-control analysis comprising 370 cases and 388 controls was conducted to evaluate the effects of the high-risk diplotype predefined as PPP1R13L rs1970764(AA)-CD3EAP rs967591(GG)-ERCC1 rs11615(AA) among Caucasians and three SNPs alone or other haplotypes combined for lung cancer risk.
|
22335888 |
2012 |