|
Malignant neoplasm of breast
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Heregulin regulation of Akt/protein kinase B in breast cancer cells.
|
10441522 |
1999 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line.
|
11429232 |
2001 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To determine if phosphatidylinositol 3-kinase/AKT signaling contributes to cell survival in HER-2/neu-positive breast cancers, we performed immunohistochemical analyses to evaluate expression of HER-2/neu and AKT in a series of 52 breast carcinomas.
|
12032855 |
2002 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Here we show that activation of protein kinase B (PKB)/Akt, contributes to resistance to antiproliferative signals and breast cancer progression in part by impairing the nuclear import and action of p27.
|
12244302 |
2002 |
|
Malignant neoplasm of breast
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
|
12244303 |
2002 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that activation of Akt1 by HER2/PI-3K plays an important role in conferring a broad-spectrum chemoresistance on breast cancer cells and that Akt may therefore be a novel molecular target for therapies that would improve the outcome of patients with breast cancer.
|
12761490 |
2003 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the relationship between PTEN-PKB and receptor status in human breast cancer.
|
12569575 |
2003 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer.
|
14681726 |
2004 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This finding thus suggested PDK-1 may promote oncogenesis in part through the activation of AKT and p70S6K and rationalised that PDK-1 as well as downstream components of PDK-1 signalling pathway may be promising therapeutic targets to treat breast cancer.
|
16288304 |
2005 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Thus, AKT-dependent increase of PED expression levels represents a key molecular mechanism for chemoresistance in breast cancer.
|
16061647 |
2005 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We determined the effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on hsp90 and its client proteins Her-2, AKT, and c-Raf, as well as evaluated the cytotoxic effects of co-treatment of SAHA with trastuzumab or docetaxel in human breast cancer BT-474 and SKBR-3 cells containing amplification of Her-2.
|
16144943 |
2005 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The cross-talk between the PI3K-AKT and ER beta pathways, as revealed by the ability of AKT to regulate several components of ER beta-mediated transcription, may represent an important aspect that may influence breast cancer response to endocrine therapy.
|
16951146 |
2006 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
|
16537497 |
2006 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways.
|
17308086 |
2007 |
|
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
|
17611497 |
2007 |
|
Malignant neoplasm of breast
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Immunohistochemical staining of primary breast cancer biopsies (n = 290) was carried out using antibodies specific for ER phosphorylated at Ser(167) and for phosphorylated p44/p42 mitogen-activated protein kinase (MAPK), phosphorylated p90RSK, and phosphorylated AKT.
|
17908967 |
2007 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human mammary epithelial cells transduced to overexpress HER-2, HER-2, PTEN, and Myr-AKT and the primary breast cancer cell lines SUM-149 and SUM-225 were used to dissect the signaling pathways leading to growth factor independence and anchorage-independent growth in HER-2 overexpressing cells.
|
17612563 |
2007 |
|
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
|
18676830 |
2008 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells.
|
19074894 |
2008 |
|
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest a unique role of AKT in modulating estrogen signaling in ERalpha-positive breast cancers and highlights how extracellular signal activated kinases can change the landscape of transcription factor binding to the genome.
|
18838536 |
2008 |
|
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
AKT phosphorylation is associated with HER2 expression but not EGFR expression in patients with early breast cancer. pAKT is not predictive for the efficacy of anthracycline-based adjuvant chemotherapy.
|
17804473 |
2008 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Since AKT signaling impacts cell survival and proliferation, in this study we investigated whether AKT activation in breast cancer cells is sensitive to perturbation of Pfn1 expression.
|
18937284 |
2009 |
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
PIK3CA, encoding the PI3K catalytic subunit, is the oncogene exhibiting a high frequency of gain-of-function mutations leading to PI3K/AKT pathway activation in breast cancer.
|
21209903 |
2010 |