|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Compared to age-matched postmenopausal controls, the ER-alpha/beta ratio was reduced in both grade I adenocarcinoma and MMMT specimens (3.3 and 6.8, respectively), due to a selective loss of ER-alpha.
|
11687977 |
2001 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Combining 4 genes (CALCA, DAPK, ESR1 and APC) yielded a sensitivity of 89% (with all adenocarcinomas identified), equal to cytomorphology (89%) and high-risk human papilloma virus (Hr-HPV; 90%).
|
16736496 |
2006 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Human adenocarcinoma cells that are either estrogen-receptor positive (such as MCF-7) or estrogen-receptor negative (such as MDA-MB-468) were used as our model system.
|
9848511 |
1998 |
|
Adenocarcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Comparison of methylation in adenocarcinoma cell lines and tumors versus non-tumor lung tissue showed methylation of ESR1, PGR1 and RASSF1 to be significantly elevated in adenocarcinoma, with RASSF1 being most significant (P=0.0002).
|
15639718 |
2005 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In Borrmann IV gastric carcinoma ER positive rate was greater than that in other pathologic types, and in poorly differentiated adenocarcinoma and signet ring cell carcinoma the positive rates were greater than those in other histological types of both males and females (P<0.05).
|
12679906 |
2003 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Such EGFR mutations are frequently found in adenocarcinoma with a strong expression of estrogen receptor (ER) beta, which has been shown to correlate with a favorable prognosis for the patients with EGFR mutations.
|
20615575 |
2011 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Some studies have shown that activation of estrogen and estrogen receptor α or β (ERα/β) promote adenocarcinoma.
|
25692143 |
2015 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunhistochemistry profiling of human endometrial cancer tissue biopsies identified epithelial cells co-expressing ERβ5 and ERα in stage I endometrial adenocarcinomas and post menopausal endometrium.
|
31778358 |
2020 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Using a script written in R, the diagnostic accuracy of all possible combinations of markers was evaluated and it was shown that a 3 marker panel including vimentin, ER, or PR, and an HPV marker (p16, ProExC, or HPV ISH) is optimal for determining site of origin for usual endometrial and endocervical adenocarcinomas.
|
20534993 |
2010 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We have introduced the human estrogen receptor (ER) gene into HeLa cells, a human adenocarcinoma cell line of uterine origin, by infection.
|
1682189 |
1991 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We examined this interplay and response to mTOR inhibition using ERα+ adenocarcinomas from NRL-PRL females in combination with Col1a1<sup>tmJae/+</sup> (mCol1a1) mice, which accumulate collagen-I around growing tumors.
|
29935374 |
2018 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, intracellular hK4 levels, as detected on Western blot analysis, were induced by 100 nM estrogen treatment of the estrogen receptor positive ovarian carcinoma cell line OVCAR-3, >8-24 h. Our results show that the level of KLK4 expression and expression of KLK4 mRNA variants are associated with progression of ovarian cancer, particularly late stage SER adenocarcinomas.
|
11489814 |
2001 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Immuno-histochemical examination of the expression of TRPM8 channels in human breast tissues revealed an over-expression of TRPM8 in breast adenocarcinomas, which is correlated with estrogen receptor positive (ER+) status of the tumours.
|
20482834 |
2010 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, we examined the expression of PGRMC1 and PGRMC2 mRNA by relative quantitative PCR (RelqPCR) and determined whether transcript levels correlate with age, breast cancer staging, estrogen receptor alpha (ERα) status, and other morphometric features routinely used during the pathological examination of breast ductal adenocarcinomas.
|
20655063 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters.
|
17046193 |
2007 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The most common breast cancer type was adenocarcinomas (59.1%) and half of the breast cancers were hormone sensitive, with estrogen receptor positive status in 10 of 19 tested and progesterone receptor positive status in 5 of 14 tested.
|
30087072 |
2018 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The objective was to characterize and associate the receptor reactivities of fibroblastic growth factor (FGF)-2, FGF-7, FGF-8, epidermal growth factor (EGF), α-actin and vimentin in relation to the androgen receptor (AR), α and β estrogen receptors (ERα and ERβ), and prolactin receptor in the prostate of elderly men showing low- and high-grade adenocarcinoma.
|
23362007 |
2013 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression of a nuclear estrogen receptor such as ERα in clinical pathology.
|
30227306 |
2018 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Most (90%) of the endometrial adenocarcinomas were positive for vimentin and estrogen receptor, all were negative for HPV, and 97% were negative for carcinoembryonic antigen.
|
23318908 |
2013 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor (ER) alpha is expressed at low levels in normal epithelia, and its expression is dramatically up-regulated as transformation progresses during mammary hyperplasia and adenocarcinoma development.
|
17108100 |
2006 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Comparison of methylation in adenocarcinoma cell lines and tumors versus non-tumor lung tissue showed methylation of ESR1, PGR1 and RASSF1 to be significantly elevated in adenocarcinoma, with RASSF1 being most significant (P=0.0002).
|
15639718 |
2005 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The results of this study show that bcl-2 is relatively highly expressed in proliferative (n = 11) and hyperplastic (n = 18) endometrium, with respective mean staining scores of 3.59 and 3.47 (scale, 0-4), but is significantly (P < 0.001) down-regulated in atypical hyperplasia (n = 11; score, 0.82), and adenocarcinoma (n = 34; score, 0.86). bcl-2 expression did not correlate with stage, grade, estrogen-receptor, or progesterone-receptor expression.
|
8729985 |
1996 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Coexpression index of estrogen receptor alpha mRNA isoforms in simple, complex hyperplasia without atypia, complex atypical hyperplasia and adenocarcinoma.
|
17561234 |
2007 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
[Profile of estrogen receptor alpha isoforms in endometrial adenocarcinoma].
|
14674143 |
2003 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
ESR1 gene multiple copies were confirmed in 13/60 (21.6%) breast adenocarcinomas, but high amplification only in 8/13 (62.8%).
|
20458558 |
2011 |