Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.
|
12524070 |
2003 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The PvuII polymorphism in the ER-α gene may be a risk factor for ULM.
|
23749503 |
2013 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Previously, we reported that fenvalerate (Fen) promotes proliferation of human uterine leiomyoma (UtLM) cells by enhancing progression of cells from G(0)-G(1) to S phase through molecular mechanisms independent of estrogen receptor-α and -β.
|
22850687 |
2012 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A T/C SNP in intron 1 and exon 2 boundary of estrogen receptor (ER) alpha gene recognized by PvuII enzyme has been associated with several female pathologies like breast cancer, osteoporosis, endometriosis and fibroids in various ethnic groups.
|
19729795 |
2009 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein.
|
27100507 |
2016 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium.
|
15474102 |
2004 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Eighty-percent of LM and 70% of the ULMS were estrogen receptor positive, whereas only one retroperitoneal tumor had focal weak positivity.
|
10574596 |
1999 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Pvu II and Xba I polymorphisms in the ER-alpha gene do not produce different risks of developing uterine leiomyomas.
|
11239543 |
2001 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
The present results imply that the increased ratio of ER alpha/ER beta observed in the fibroids after GnRHa treatment could reflect or be the cause of the shrinkage of the leiomyoma, which is the clinical outcome of this treatment.
|
11826769 |
2001 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
On the other hand, estrogen receptor-alpha (ER-alpha) mRNA is hyper-expressed in 67% of the leiomyomas as compared to their paired myometrium.
|
11232041 |
2001 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Paradoxically, neither 17 beta-estradiol nor bFGF was capable of up-regulating Cyr61 mRNA in leiomyoma explants despite elevated levels of ER alpha mRNA, suggesting a possible defect in steroid and growth factor regulation.
|
11297607 |
2001 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Estrogen stimulates cell proliferation through binding to the estrogen receptor (ER), of which both subtypes α and β are present in leiomyomas.
|
26529545 |
2016 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
One extrauterine, retroperitoneal estrogen receptor-positive leiomyoma was also FH deficient.
|
27454940 |
2016 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
ERα inhibited myocardin-induced differentiation in uterine fibroids.
|
27871850 |
2017 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, our findings provided little support for the association of these SNPs on ESR1 with leiomyoma.
|
16935316 |
2006 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Dominant-negative estrogen receptor gene therapy may provide a nonsurgical treatment option for women with symptomatic uterine fibroids who want to preserve their uteri.
|
15547533 |
2004 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
|
9780024 |
1998 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The level of messenger RNA expression of estrogen receptor alpha and beta and the level of estrogen receptor as a whole are increased on average to a similar extent in leiomyomas compared with normal myometrium.
|
18166184 |
2008 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
The results presented here suggest that some exogenous ER ligands may mimic the effects of endogenous estrogens on uterine leiomyoma and may contribute to a complex hormonal milieu that impacts both normal and neoplastic myometrium.
|
10397250 |
1999 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Carriage of the ESR1 IVS1-397 T/C (PvuII), COMT G158A, and the CYP17A 34T-->C SNPs is not associated with the susceptibility to uterine leiomyoma in a Caucasian population.
|
16595228 |
2006 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Our in vivo data in a mouse model demonstrate the ability of an adenovirus-expressing dominant-negative ER to arrest leiomyoma growth.
|
16603566 |
2006 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
CTD_human |
In conclusion, there was an aberrant DNA methylation status in the promoter region of ER-alpha gene in uterine leiomyoma, which may be associated with high ER-alpha mRNA expression.
|
18701604 |
2008 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor subtype alpha mRNA levels were significantly, and 1.8- to 2.6-fold, higher in leiomyoma compared with adjacent myometrium in all groups, whereas leiomyoma estrogen receptor subtype beta mRNA levels were significantly elevated only in Japanese women.
|
19240151 |
2009 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to analyze the effect of ERα-351 XbaI A/G, ERα-397 PvuII T/C, and progesterone receptor (PGR) PROGINS polymorphisms on the development of leiomyomas.
|
30390345 |
2019 |