|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
An analysis of the human estrogen receptor (ER) mRNA was performed on 71 human breast tumors using an RNase protection assay.
|
2459605 |
1988 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Expression of TGF alpha mRNA was detected in 70% of estrogen receptor positive and negative primary human breast tumors from 40 patients when examined by slot blot and Northern analysis.
|
3047554 |
1988 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Initial studies in human breast cancer cell lines suggested a possible association between the absence of one allele and the absence of ER expression; subsequent analysis of allele distribution and frequency in 188 primary human breast tumor biopsies did indeed show a significant but not complete correlation between the absence of one allele and the failure to express ER.
|
2562795 |
1989 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Thirty to 40% of estrogen receptor (ER) positive human breast tumors are resistant to endocrine therapy.
|
2725532 |
1989 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Since sex steroid hormones and growth factors are known to modulate the proliferation of breast tumors, we have studied the effects of estrogen and progestin, their antagonists, and growth factors on the regulation of estrogen receptor (ER) mRNA and protein levels in T47D breast cancer cells, which contain low levels of ER, and in two sublines of MCF-7 cells which contain high ER levels.
|
2785242 |
1989 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen. A comparative analysis in breast cancer.
|
2194831 |
1990 |
|
Mammary Neoplasms
|
0.500 |
PosttranslationalModification
|
group |
BEFREE |
Estrogen receptor gene methylation in human breast tumors.
|
2354445 |
1990 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Furthermore, it has been suggested that EGF-R levels are higher in estrogen receptor negative (ER-) than in ER+ human breast tumors and that EGF-R status may be a prognostic indicator in breast cancer.
|
2206558 |
1990 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
It was found that 89.4% of the ER mRNA-positive breast tumor biopsies had detectable EGF mRNA, whereas only 58.3% of the ER mRNA-negative tumors had detectable EGF mRNA.
|
2364377 |
1990 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Therefore, this PCR technique may be useful in the detection and cloning of rare ER transcripts from breast tumor biopsy specimens.
|
2332903 |
1990 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
It is concluded that ER gene amplification may be one of the mechanisms underlying the increased ER expression in some breast tumors.
|
2302226 |
1990 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
No rearrangement or amplification of the ER gene was seen in either ER-positive or ER-negative breast tumors.
|
2576351 |
1990 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Variant human breast tumor estrogen receptor with constitutive transcriptional activity.
|
1988075 |
1991 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Using a fragment of the estrogen receptor (ER) cDNA as a probe, Southern blots of HindIII-digested genomic DNA, from breast tumours and non-cancerous tissue, revealed a 1.6 kb hybridizing fragment (1.6KbHF) in 3 out of 30 tumours, and in 31 out of 80 mastectomy samples (16 sectors from each of 5 patients), which was significantly correlated with the absence of progesterone receptor.
|
2018347 |
1991 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In estrogen receptor-positive (ER+) breast tumors, the variant allele was preferentially associated with lower levels of ER, and was clinically correlated with frequent spontaneous abortions.
|
1756270 |
1991 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In this study we investigated IGFBP mRNA expression and IGFBP content in relation to ER content in human breast tumors.
|
1382838 |
1992 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent evidence suggests that the progression to hormone resistance in some breast tumors is due to mutations in the estrogen receptor (ER).
|
1362141 |
1992 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We focused upon this group of patients and have identified a truncated ER which is abundant in some ER+/PgR- breast tumors and which inhibits the binding of wild-type ER to its cognate response element.
|
1728420 |
1992 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We have used in vitro DNA binding assays as a measure of estrogen receptor (ER) function in human breast tumors.
|
8219256 |
1993 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
The presence of this ER variant in breast tumor cell lines, as well as breast tumor biopsies and uterine tissue, suggests that it is a naturally occurring variant that may arise by alternative splicing, and whose overexpression may be involved in the progression of breast tumors to a hormone-independent state.
|
8261406 |
1993 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results clearly indicate that the three derivatives behave like estrogens and that they would be excellent candidates for imaging or monitoring ER-containing breast tumors.
|
8439515 |
1993 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In a preliminary study on women with estrogen receptor positive (ER+) breast tumors, we found that the presence of the rarer of the two alleles, the B' allele, is correlated with a history of spontaneous abortion.
|
8219254 |
1993 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
The relative expression and transcript size of ER mRNA and TRPM-2 mRNA in 126 primary breast tumors were measured by Northern analysis and compared with tumor grade, hormone receptor status, extent of tumor necrosis, and survival.
|
8252481 |
1993 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
RAR alpha and ER mRNA expression were determined by Northern blot analysis in 116 primary breast tumors; 94 (81%) tumors were ER-positive and of these 87 (93%) were also RAR alpha-positive.
|
8261407 |
1993 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
An alternatively spliced mRNA coding for a variant estrogen receptor (ER) missing exon 4 (ERdelta4) was detected in the breast tumor cell line MCF7 and meningioma tissue by using the reversed transcriptase PCR technique.
|
9397958 |
1994 |