Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ETV6: a versatile player in leukemogenesis.
|
15826831 |
2005 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TEL-AML1 hybrid protein thought to be critical in leukemogenesis possesses the HLH domain of TEL fused to almost the entire AML1 protein, although the detailed mechanisms of leukemogenesis remain obscure.
|
9498702 |
1997 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional genetic changes, such as ETV6 loss, extra RUNX1, ETV6/RUNX1 duplication, and MLL aberrations in the ETV6/RUNX1-positive group, supported the hypothesis of the ETV6/RUNX1 leukemogenic model that these secondary changes are necessary for leukemogenesis rather than progression of disease.
|
18728978 |
2008 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although ETV6 translocations are infrequent in acute myeloid leukemia (AML), mutations or deregulated expression of ETV6 may contribute to leukemogenesis.
|
15806161 |
2005 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both abnormalities affect the reciprocal RUNX1-ETV6 fusion product which could either eliminate or amplify its expression and thus contribute to leukemogenesis.
|
23077088 |
2013 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
EPOR mRNA is selectively and ectopically expressed in ETV6-RUNX1(+) ALL, but the presence of a functional EPOR on the cell surface and its role in leukemogenesis driven by ETV6-RUNX1 remains to be identified.
|
21900195 |
2011 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
FISH analysis with the use of the YAC 936e2 probe, which covers the TEL gene, did not show the split signal, suggesting that a gene other than TEL was involved in the leukemogenesis of the present case.
|
10549263 |
1999 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene expression profiling provided evidence that leukemia in twins harbours the same subtype-typical feature as TEL-AML1-positive leukemia in singletons suggesting that the leukemogenesis model might also be applicable generally.
|
15356660 |
2004 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we addressed the role of MN1-TEL in myeloid leukemogenesis using the same mouse model.
|
16105979 |
2005 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we show in a murine model of t(12;13)(p13;q12) AML that myeloid leukemogenesis is induced by the ectopic expression of CDX2 and not by the ETV6-CDX2 chimeric gene.
|
14718672 |
2004 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, using the TEL-JAK2 transgenic (TJ2-Tg) mouse model of T-ALL/LBL, which is driven by constitutive JAK/STAT signaling and characterized by the acquisition of Notch1 mutations, we sought to identify stromal cell alterations associated with thymic leukemogenesis.
|
30256907 |
2018 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the transforming activity of the ETV6/ARG protein has not been determined and its contribution to leukemogenesis is therefore unknown.
|
12080468 |
2002 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.
|
12764377 |
2003 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis.
|
26584717 |
2015 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to fusion of TEL to the PDGF beta receptor in t(5;12) in chronic myelomonocytic leukemia (CMML), our data suggest that the involvement of this protein in myeloid leukemogenesis could be dual; its isolated protein-protein dimerization and DNA-binding domains may be crucial for the oncogenic activation of functionally different fusion proteins.
|
7731705 |
1995 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to mutations in genes known to be involved in leukemogenesis (ETV6, NOTCH1, JAK1, and NF1), we identified novel recurrent mutations in FAT1 (25%), FAT3 (20%), DNM2 (35%), and genes associated with epigenetic regulation (MLL2, BMI1, and DNMT3A).
|
23603912 |
2013 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is likely that ETV6 is frequently involved in leukemogenesis because of the large number of partners with which it can rearrange and the several pathogenic mechanisms by which it can lead to cell transformation.
|
22578774 |
2012 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of tumor suppressive function of wild-type TEL and maintenance of STAT3-mediated signal could at least partly contribute to the leukemogenesis caused by inv(12)(p13q13).
|
16061641 |
2005 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MN1-TEL contributes to leukemogenesis by a mechanism distinct from that of other chimeric proteins containing TEL.
|
11094079 |
2000 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, it was shown that the AML1-ETV6 reciprocal chimeric transcript was not present in the malignant cells, and hence may not play a major role in leukemogenesis.
|
8653712 |
1996 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nevertheless, functional studies would be needed to establish the biological role of AIF1L-ETV6 and ABL1-AIF1L and to determine whether they contribute to leukemogenesis and/or to the final leukemia phenotype.
|
29726059 |
2018 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data on increased DSB levels in the BCR-ABL/TEL-AML1 patient's cells support a model where BCR-ABL/TEL-AML1 induces DNA instability through facilitating mutagenesis and appearance of additional genetic alterations driving leukemogenesis.
|
25244981 |
2014 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study provides a unique insight into the role of TEL-AML1 in leukemia predisposition and a potential model to study the mechanism of leukemogenesis associated with this fusion.
|
14726384 |
2004 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, our findings indicate that activin A, in concert with TGF-β, could play an important role in the creation of a pro-oncogenic BM microenvironment and provide novel mechanistic insights into TEL-AML1-associated leukemogenesis.
|
30825516 |
2019 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, these findings indicate that TEL-AML1 contributes to leukemogenesis and may cooperate with loss of p16(INK4a)p14(ARF) to transform lymphoid progenitors.
|
12124316 |
2002 |