|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to malignant melanoma but a distinct genetic background including a chromosomal translocation, t(12;22)(q13;q12), or a resultant EWSR1-ATF1 fusion gene.
|
18300804 |
2008 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional profiling was performed in three tumors and their gene expression was compared to five clear cell sarcomas expressing either the EWSR1-ATF1 or EWSR1-CREB1 fusion.
|
17724745 |
2007 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
EWSR1-ATF1 also represents the most frequent genetic alteration in clear cell sarcoma, suggesting the existence of a molecular homology between these two histotypes.
|
18094413 |
2007 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a novel variant fusion of EWS to CREB1, a gene at 2q32 encoding another CREB family member highly related to ATF1, detected in three women with gastrointestinal CCS.
|
17000668 |
2006 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
FISH detects EWS gene rearrangement in a substantial proportion of clear cell sarcomas, with excellent specificity.
|
16258500 |
2005 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interphase FISH using this newly developed probe is sensitive and specific for detecting the EWS gene on FFPE tissues and is of value in the routine clinical diagnosis of ES/PNET, DSRCT, and CCS.
|
16189150 |
2005 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
RT-PCR and sequence analysis revealed the presence of a fusion transcript bringing together exon 7 of EWS with exon 5 of ATF1, consistent with a type 2 transcript reported in association with CCS.
|
16327442 |
2005 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of the EWSR1-ATF1 oncogene is probably an early step in the transformation process, but the overall gene expression patterns are likely to vary considerably between AFH and CCS, in keeping with their clinicopathologic differences.
|
15884099 |
2005 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
Biomarker
|
disease |
LHGDN |
Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses.
|
11992546 |
2002 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
Biomarker
|
disease |
BEFREE |
New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts).
|
9824209 |
1998 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of malignant melanoma of soft parts or soft tissue clear cell sarcoma which shares t(12;22) chromosome translocation revealed fusion of EWS with a transcriptional factor gene ATF-1.
|
8552387 |
1996 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The different translocation partners of the EWS gene, all of which are putative or definite transcription factor genes, may be responsible for the biological differences between DSRCT, Ewing's sarcoma, and clear cell sarcoma.
|
8187063 |
1994 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In Ewing's sarcoma and malignant melanoma of soft parts, translocations of band 22q12 to chromosome 11 and 12 result in the fusion of EWS with the transcription factors FLI-1 and ATF1, respectively.
|
8223458 |
1993 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.
|
8401579 |
1993 |