|
Acquired Kyphoscoliosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Active tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
HBsAg positivity was 12.2%, HCVAb 3.3%, HIVAb 1.6%, TPPA+RPR positivity in the 0.7%; 10.2% had a positive Mantoux test; 5.6% had Chest X-rays positive for signs of infection and 6 patients had an active tuberculosis.
|
30377049 |
2019 |
|
Acute pulmonary embolism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upon evaluation of the diagnostic differentiation of these risk factors for massive APE by employing receiver operating characteristic curve analysis, it was determined that PLR (AUC±SE=0.877±0.015; P<.001), and NLR (AUC±SE=0.893±0.013; P<.001) have similar diagnostic differentiation in diagnosing massive APE and these two parameters are superior over PASP, MPR, WMR, and RPR.
|
27709684 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
25429064 |
2015 |
|
Brachydactyly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We have examined the effects of a replication-defective adenovirus encoding p53 (RPR/INGN 201 [Ad5CMV-p53]; Adp53), alone or in combination with the breast cancer therapeutic doxorubicin (Adriamycin), to suppress growth and induce apoptosis in breast cancer cells in vitro.
|
11339893 |
2001 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer.
|
10427123 |
1999 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In view of its putative tumor suppressor function, the EXTL3 gene can be considered a candidate gene for the breast cancer locus on chromosome 8p12-p22.
|
9479495 |
1998 |
|
Broad nasal tip
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ad5CMVp53 (RPR/INGN 201) has previously shown promise in both patients with lung cancer and those with head and neck cancer.
|
10854146 |
2000 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Direct administration of RPR/INGN 201 to the lower airways of patients with bronchioalveolar cell lung carcinoma resulted in symptomatic improvement and improved lung function in some patients.
|
12749760 |
2003 |
|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Precompacting DNA with a histone H1-derived peptide enhances cationic lipid RPR 115335-mediated gene transfer in an in vivo model of Lewis lung carcinoma.
|
10435113 |
1999 |
|
Cirrhosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
VCTE demonstrated excellent diagnostic accuracy for the detection of cirrhosis with an AUROC of 0.90 compared with APRI (0.83), FIB-4 (0.88), AAR (0.73) and RPR (0.85).
|
31742822 |
2020 |
|
Cirrhosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further comparisons showed the diagnostic performance of GPR was not significantly different with APRI, FIB-4 and RPR in identifying significant fibrosis, advanced fibrosis and cirrhosis, but it was significantly superior to AAR and NLR in both HBeAg positive CHB and HBeAg negative CHB.
|
28819319 |
2017 |
|
Clumsiness - motor delay
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Coarse facial features
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cocaine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, this pilot study suggests that RPR 102681 would be unlikely candidate, as an agonist medication for the treatment for cocaine addiction but worth investigating further for possible role in reducing craving.
|
29923314 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
The presence of EXTL3 methylation was significantly associated with the partial loss of HS expression in mucinous CRC lesions.
|
18543267 |
2008 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although there is still no definitive evidence that EXTL3 is a tumor suppressor gene for CRC, these data suggest that inactivation of the EXTL3 gene may at least offer a selective growth advantage for some CRC cell lines.
|
10536173 |
1999 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes.
|
17106246 |
2006 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, GPR does not show advantages than APRI, FIB-4 and RPR in identifying significant liver fibrosis, advanced liver fibrosis and liver cirrhosis in both HBeAg positive CHB and HBeAg negative CHB in China.
|
28819319 |
2017 |
|
Congenital dislocation of radial head
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Congenital kyphoscoliosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We screened patients with stable coronary artery disease for cytochrome P450 (CYP) 2C19 genotypes and enrolled 103 patients who lacked CYP2C19*2 or *3 loss-of-function allele to minimize the effect of this gene on high RPR.
|
23922147 |
2013 |