|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Factor (F)V Leiden and the G20210A prothrombin mutation (PTM) may play a role in causing catheter-related DVT in patients with cancer.
|
17988232 |
2008 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with prothrombin G20210A had a younger age at their first VTE (24 years, P < 0.0001) and a higher rate of DVT accompanying PE (P = 0.04) than those with FV Leiden or no thrombophilia.
|
17067362 |
2007 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a multivariate analysis adjusting for age, sex, presence of factor V Leiden and carriage of prothrombin 20210A, homozygosity for the FGG 10034 TT genotype yielded an odds ratio of 2.01 (95% CI 1.23-3.31; p=0.006) for DVT.
|
17445871 |
2007 |
|
Deep Vein Thrombosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The efficiency of a new prothrombin-based activated protein C (APC) resistance test to detect factor V Leiden (FVL) was clinically evaluated in 150 Italian patients with deep venous thrombosis.
|
17890946 |
2007 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations are associated with increased risk of deep venous thrombosis, pulmonary embolism, and obstetric complications.
|
17145624 |
2007 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Deep venous thrombosis in a patient with Behçet's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills.
|
16189654 |
2006 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The impact of the G20210A prothrombin mutation, factor V Leiden and 677T mutation of methylene tetrahydrofalate reductase (MTHFR) in recurrent deep venous thrombosis (DVT) is not so clear.
|
16607075 |
2006 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in our studied population, factor V Leiden, APC resistance, and prothrombin G20210A were associated with an increased risk of deep vein thrombosis.
|
16917913 |
2006 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
While FV-Leiden was a common genetic risk factor for DVT in both communities, the contribution of PRT G20210A to the genetic susceptibility of DVT differed among Lebanese and Tunisians, which underscores the need to determine prothrombotic gene polymorphisms associated with DVT among Arab and Mediterranean basin communities.
|
16823828 |
2006 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The odds ratio for the prothrombin G20210A was approximately twice that for lower limb DVT.
|
15726653 |
2005 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This indicates that FV-Leiden and PRT G20210A, more than MTHFR C677T, are important risk factors for DVT, and that the presence of more than one prothrombotic SNPs was associated with a significant risk of DVT.
|
16082606 |
2005 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The adjusted odds ratio for upper-extremity DVT was 6.2 (95% CI 2.5 to 15.7) for factor V Leiden, 5.0 (95% CI 2.0 to 12.2) for prothrombin G20210A, and 4.9 (95% CI 1.1 to 22.0) for the anticoagulant protein deficiencies.
|
15262837 |
2004 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association between factor V Leiden mutation and G20210A mutation in the 3'-untranslated region of the prothrombin gene with DVT was found.
|
15077257 |
2004 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To analyze the influence of the prothrombotic gene mutation factor V G1691A (factor V Leiden) and prothrombin G20210A on the risk of a first episode of catheter-related deep venous thrombosis (DVT) in a group of patients with breast cancer treated with chemotherapy.
|
15033664 |
2004 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report the case of a 30-year-old woman heterozygous for both the prothrombin 3' UTR mutation and for the factor V Leiden mutation who presented with a proximal deep vein thrombosis following in vitro fertilization.
|
12879433 |
2003 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Higher D-dimer concentration was associated with the risk of DVT, and was supra-additive to the risks associated with factor V Leiden and the prothrombin 20210A variant.
|
11858188 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic analysis revealed that the presence of LA, aCL, anti-beta2-glycoprotein I, anti-prothrombin and anti-protein C Abs was not reliable as a risk factor for DVT in non-SLE patients, and that the presence of anti-protein S Abs was the most significant risk factor for DVT (OR, 5.88; 95% CI, 1.96-17.7; p < 0.002).
|
12428083 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Furthermore, the risk of recurrent deep venous thrombosis in heterozygous carriers of both factor V Leiden and prothrombin gene mutations is high enough that some investigators suggest lifelong warfarin prophylaxis for these individuals, even with a single spontaneous thrombotic event.
|
12296757 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The G20210A mutation variant of prothrombin gene is the second most frequent mutation identified in patients with deep venous thrombosis, after factor V Leiden.
|
12067473 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, the 19911A/G genotype slightly increased the risk of developing DVT in carriers of the 20210G/A genotype (OR 3.34 vs 5.86), supporting that the prothrombin 19911 polymorphism could modulate the risk of the G20210A polymorphism in developing DVT.
|
12139755 |
2002 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT).
|
11441986 |
2001 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of factor V Leiden and prothrombin 20210 A variant in Bulgarian patients with pulmonary thromboembolism and deep venous thrombosis.
|
11734663 |
2001 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Odds ratio of the PlA2 allele for DVT was 1.21 (95 percent CI 0.85-1.71, p=0.29) and remained insignificant after adjustment for factor V Leiden and prothrombin 20210A genotypes (1.22, 95 percent CI 0.86-1.75, p=0.27).
|
11533523 |
2001 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the carriers of the prothrombin mutation should be treated with oral anticoagulants after a first deep venous thrombosis for a similar length of time as patients with a normal genotype.
|
11380448 |
2001 |
|
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We determined the prevalence of factor V Leiden and of prothrombin G20210A mutations in a cohort of unselected outpatients (n = 748) referred for suspected deep vein thrombosis (DVT) and/or pulmonary embolism (PE) and a pooled analysis of similar studies was also performed.
|
10930988 |
2000 |