|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Proteinase-activated-receptor 1 (PAR-1) and epidermal growth factor (EGF) have been shown to mediate the regulation of local and early-onset angiogenesis, and in turn may impact the process of tumor growth and disease progression.
|
20101173 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data suggest PAR1 overexpression may be involved in the development of metastases in breast cancer patient and is associated with undifferentiated cellular progression of the tumor.
|
19538737 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor tissue showed increased mRNA levels for PAR-1 but not PAR-2.
|
19424642 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protease-activated receptor-1 (PAR-1) is a key player in melanoma metastasis with higher expression seen in metastatic melanoma cell lines and tissue specimens. cDNA microarray and Western blot analyses reveal that the gap junctional intracellular communication molecule connexin 43 (Cx-43), known to be involved in tumor cell diapedesis and attachment to endothelial cells, is significantly decreased after PAR-1 silencing in metastatic melanoma cell lines.
|
19679555 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, we demonstrate that PAR1 expression in invasive breast carcinoma is essential for tumor growth in vivo assessed by mammary fat pad xenografts.
|
18372913 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Significant decreases in tumor growth, weight, and metastatic lung colonies (P < 0.001 for all) were found in mice treated with PAR-1 siRNA-DOPC.
|
18974154 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Proteinase-activated receptor-1 (PAR(1)), a thrombin receptor and the prototype of a newly discovered G-protein-coupled receptor subfamily, plays an important role in tumor development and progression.
|
17323377 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed that hPar1 antisense clones exhibit low PAR1 levels, attenuated cell proliferation and invasion in vitro, and tumor formation in vivo.
|
17374729 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protease-activated receptor 1 (PAR1) is emerging with distinct assignments in tumor biology.
|
16707447 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data underline the essential role of the tumor microenvironment and of several commutators targeting cGMP/PKG signaling and the RhoA-ROK axis in the control of PAR-1 proinvasive activity and metastatic potential of cancer cells in distant organs and peritoneal or pleural cavities.
|
16091733 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present result indicate that 5-HTRs are present at various tumour stages and that antagonists to these receptors can inhibit the proliferative activity of androgen-independent PC cell lines.
|
15925089 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The metastatic tumors showed a lower percentage of PAR-1-positive cells (46%) and lower levels of PAR-1 expression (median weight index = 10) than node negative primary tumors (80% and median weight index = 60, respectively).
|
15625067 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma.
|
12645337 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
By in vivo injection of either Matrigel plugs containing Par1-expressing cells or of rat prostatic carcinoma cells transfected with tetracycline-inducible Par1 expression vectors, we show that Par1 significantly enhances both angiogenesis and tumor growth.
|
12554695 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results can explain the angiogenic and tumour-promoting effect of thrombin and provide the basis for development of thrombin receptor mimetics or antagonists for therapeutic application.
|
12023846 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PAR-1 plays an important role in the progression of different solid tumours in vitro.
|
11964083 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis.
|
11395381 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These genes encode the oncogenic Tyro3 tyrosine kinase receptor, the heparin-binding epidermal growth factor-like growth factor (HB-EGF) that is an epithelial autocrine tumor growth factor, the thrombin receptor (TR) that is linked to HB-EGF and syndecan-1 processing and to cell invasion, chemokine receptors CCR1 and CCR2, the Wnt pathway actor Frizzled-related protein (FRZB), and the Notch receptor ligand Jagged 2.
|
11468178 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of the thrombin receptor in tumor cell metabolism still is undefined.
|
9392328 |
1997 |