|
Alcoholic Intoxication, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
A protective effect of ALDH I deficiency against alcoholism seems to exist in Japanese.
|
6356157 |
1983 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The results indicate that Japanese with the atypical ALDH2(2) allele are at a much lower risk in developing the alcoholic liver diseases than are those with homozygous, usual (Caucasian-type) ALDH1(2)/ALDH1(2), presumably owing to their sensitivity to alcohol intoxication.
|
3189338 |
1988 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
BEFREE |
The results indicate that Japanese with the atypical ALDH2(2) allele are at a much lower risk in developing the alcoholic liver diseases than are those with homozygous, usual (Caucasian-type) ALDH1(2)/ALDH1(2), presumably owing to their sensitivity to alcohol intoxication.
|
3189338 |
1988 |
|
Liver diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.
|
3189338 |
1988 |
|
Alcoholic Liver Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The results indicate that Japanese with the atypical ALDH2(2) allele are at a much lower risk in developing the alcoholic liver diseases than are those with homozygous, usual (Caucasian-type) ALDH1(2)/ALDH1(2), presumably owing to their sensitivity to alcohol intoxication.
|
3189338 |
1988 |
|
Alcoholic Intoxication, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
ALDH I deficiency is one of the important genetic factors in regulating alcohol consumption and plays a protective role against alcoholism.
|
2806215 |
1989 |
|
Flushing
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
On the premise that alcohol flushing in Caucasians could be related to ALDH1 abnormalities, we examined the enzyme properties and electrophoretic mobilities of ALDH1 partially purified from red blood cells of nine unrelated alcohol flushers.
|
2729894 |
1989 |
|
Flushing
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic abnormalities of the ALDH1 locus are also associated with alcohol flushing.
|
7695785 |
1994 |
|
Flushing
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Low erythrocyte ALDH1 activity was found in all Caucasians (n = 30) who showed the alcohol-induced flushing reaction.
|
7986281 |
1994 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point similar to that of ALDH1.
|
7779080 |
1995 |
|
Liver neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point similar to that of ALDH1.
|
7779080 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because resistance to cyclophosphamide has been correlated with increased levels of expression of the aldehyde-dehydrogenase (ALDH1) gene in tumor cell lines in vitro, we tested whether ALDH1 overexpression could directly induce cyclophosphamide resistance.
|
8562935 |
1996 |
|
Alcoholic Intoxication, Chronic
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
Because the promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism.
|
14506398 |
2003 |
|
Alcoholic Intoxication, Chronic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Because the promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism.
|
14506398 |
2003 |
|
Schizophrenia
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In patients suffering from schizophrenia we found ALDH1 expression at normal levels in DA cells of SN but at significantly reduced levels in those of the VTA.
|
14678778 |
2003 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
In patients suffering from schizophrenia we found ALDH1 expression at normal levels in DA cells of SN but at significantly reduced levels in those of the VTA.
|
14678778 |
2003 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A marked reduction of ALDH1 expression was seen in surviving neurons of SN pars compacta but not of those in the VTA in Parkinson's disease.
|
14678778 |
2003 |
|
Alcoholic Intoxication, Chronic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Individuals with an ALDH1A1*2 allele had lower rates of alcohol dependence and regular tobacco use than those without this allele.
|
15597079 |
2004 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Renal Cell Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Chromophobe Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Sarcomatoid Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Collecting Duct Carcinoma of the Kidney
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Papillary Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential protein profiling in renal-cell carcinoma.
|
15108329 |
2004 |
|
Substance Use Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Results from this study suggest that ALDH1A1*2 may be associated with protection from the development of alcohol and other substance use disorders.
|
15597079 |
2004 |